左西孟旦对急性失代偿性心力衰竭患者心脏血流动力学及心腔内血液流场的影响

Effects of levosimendan on cardiac hemodynamics and intracardiac blood flow in patients with acute decompensated heart failure

目的 探讨左西孟旦对急性失代偿性心力衰竭患者心脏血流动力学及心腔内血液流场的影响.方法 选择山西医科大学第二医院2016年1月至2017年12月收治的急性失代偿性心力衰竭患者98例,按抽签法将其分为两组.对照组49例采用常规治疗,观察组49例在常规治疗基础上加用左西孟旦,比较两组心脏血流动力学、心腔内血液流场指标.结果 观察组右房压、肺动脉平均压、肺毛细血管楔压水平均低于对照组,差异有统计学意义（P〈0.05）;治疗后,观察组等容收缩期、快速射血期、缓慢射血期、等容舒张期、快速充盈期、缓慢充盈期、心房收缩期时心尖二腔心切面、心尖四腔心切面及心尖三腔心切面的切面相能量损耗值均优于对照组,差异有统计学意义（P〈0.05）.结论 急性失代偿性心力衰竭患者采用左西孟旦治疗可调节心脏血流动力学,改善心腔内血液流场状态.

Objective To investigate effects of levosimendan on cardiac hemodynamics and intracardiac blood flow in patients with acute decompensated heart failure .Methods Ninety-eight patients with acute decompensated heartadmitted to Second Hospital of Shanxi Medical University from January 2016 to December 2017 were selected and divided into two groups according to ballot method .In control group , 49 cases were given routine treatment , and 49 cases in observation group were treated with levosimendan on the basis of routine treatment .The hemodynamic and intracardiac blood flow of the two groups were compared .Results The level of right atrial pressure , pulmonary artery mean pressure and pulmonary capillary wedge pressure in observation group were lower than those in control group , and the difference was statistically significant （ P 〈0.05 ） .After treatment , the energy loss values of apical twochamber view , apical four-chamber view and apical three-chamber view at isovolemic systole , rapid ejection , slow ejection , isovolumic diastole , rapid filling , slow filling and atrial systole in observation group were all superior to those in control group , and the difference was statistically significant （ P 〈0.05 ） .Conclusions Levosimendan can modulate cardiac hemodynamics and improve the blood flow state in patients with acute decompensated heart failure .