过渡金属催化N-烷氧基芳香酰胺邻位碳氢键官能团反应的研究进展

Progress in Transition-metal-catalyzed Ortho C—H Functionalization of N-Alkoxy Aromatic Amides

过渡金属催化的C—H键活化/官能团化反应一直是有机合成领域的研究热点之一,而N-烷氧基酰基（—CONHOR）作为一种有效的导向基团已被广泛应用于C—H键活化/官能团化反应中,大大拓展了C—H键活化反应的应用范围。按照不同种类的金属催化剂和反应类型进行分类,针对近几年N-烷氧基酰胺作导向基的情况,对芳香酰胺邻位碳氢键活化/官能团化的研究进展进行了综述。

Transition-metal-catalyzed C—H activation/functionalization has been one of the hot topics in organic synthesis. The—CONHOR as an efficient directing group has been widely used in C—H activation/functionalization reactions,which greatly expanded the scope of C—H activation reactions.Based on the different metal catalysts and reaction types,the recent research progress in the ortho C—H activation/functionalization of aromatic amides in the case of —CONHOR as a directing group has been summarized in this work.