2-甲基-4-氰基苯甲酸甲酯一步法制备2-甲基-4-甲醛肟基苯甲酸甲酯

2-Methyl-4-formaldehyde Oxime Benzoate Methyl Ester is Prepared from 2-Methyl-4-cyanobenzoic Acid Methyl Ester by One-step Reaction

肟类化合物具有优异的杀菌、杀虫、杀螨、植物生长调节、抗肿瘤、抗病毒等生物活性。对该类化合物的分子设计、有机合成与生物活性的研究是药物化学和农药研究的热点之一。以2-甲基-4-氰基苯甲酸甲酯为原料,与盐酸羟胺在碳酸钠碱性条件下一步反应直接制得目标化合物,接着对目标化合物进行IR、MS、UV、1HNMR和13CNMR表征和结构确定。采用氰基化合物为前体一步反应即可得到肟类化合物,操作简单、方便,适用于大规模生产。

Oxime-based compounds have been received considerable attention by pesticide and pharmaceutical chemists for their excellent bactericidal,insecticidal,acaricidal,plant growth regulating,antitumor,and antiviral bioactivities.At present,the research on molecular design,synthesis and biological activity of these compounds are still one of the hot topics in chemistry.4-（ hydroxyimino-methyl）-2-methyl benzoic acid methyl ester was synthesized by reaction of 4-cyano-2-methyl-benzoic acid methyl ester with hydroxylamine hydrochloride in the presence of Na2 CO3.Target compound was fully characterized and confirmed by IR,MS,UV,1 HNMR and 13CNMR.Using a cyano compound as a precursor to obtain oxime compound by one-step reaction,which is simple,convenient and suitable for mass production.