清金化痰汤治疗急性加重期慢性阻塞性肺疾病50例

Fifty Cases of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Treated with Lung-Clearing and Phlegm-Transforming Decoction

目的:观察清金化痰汤治疗慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的临床疗效。方法:将100例AECOPD患者随机分为观察组和对照组,每组各50例。对照组给予常规综合治疗,观察组在对照组的基础上加用清金化痰汤。比较两组患者的临床疗效及治疗前后中医证候积分、血气分析指标[pH、血氧分压(partial pressure of oxygen,Pa O2)]、肺功能指标[用力肺活量(forced vital capacity,FVC)、一秒用力呼气容积(Forced expiratory volume in one second,FEV1)]水平。结果:观察组有效率为96. 00%,对照组的有效率为82. 00%,差异有统计学意义(P <0. 05)。两组患者治疗后各项中医证候积分低于治疗前,且观察组低于对照组,差异有统计学意义(P <0. 05)。两组患者治疗后pH、Pa O2、FVC、FEV1、FEV1/FVC水平均显著高于治疗前,且观察组高于对照组,差异有统计学意义(P <0. 05)。结论:清金化痰汤治疗AECOPD疗效确切,可改善患者临床症状和肺功能指标。

Objective： To observe the clinical curative effect of Lung-Clearing and Phlegm-Transforming Decoction on acute exacerbation of chronic obstructive pulmonary（AECOPD）. Methods： One hundred patients with AECOPD were randomly divided into the observation group and the control group,with 50 cases in each group. The ones in the control group were given routine comprehensive treatment,while the ones in the observation group were additionally given Lung-Clearing and Phlegm-Transforming Decoction on the basis of the control group. The two groups clinical efficacies,the scores of TCM syndromes,blood analysis indexes including pH,partial pressure of oxygen（Pa O2）,lung function indexes including forced vital capacity（FVC） level,and forced expiratory volume in one second（FEV1） level before and after the treatment were compared. Results： The effective rate of observation group was 96. 00%,and that of control group was 82. 00%. The difference was statistically significant（P〈0. 05）. After the treatment,the scores of TCM syndromes of the two groups were lower than those before the treatment,and the observation group was lower than the control group,the difference was statistically significant（P〈0. 05）. The levels of pH,Pa O2,FVC,FEV1 and FEV1% in the two groups after the treatment were significantly higher than those before the treatment,and the observation group was higher than the control group,the differences were statistically significant（P〈0. 05）. Conclusion： In terms of treating AECOPD,Lung-Clearing and Phlegm-Transforming Decoction can improve clinical efficacy,blood qi analysis and pulmonary function indexes.