三伏灸配合肠内营养治疗儿童变异性哮喘临床研究

Dog Day Moxibustion Clinical Effect of Enteral Nutrition in Children with CVA Mechanism and Treatment

目的:观察三伏灸配合肠内营养治疗儿童咳嗽变异性哮喘(cough variant asthma,CVA)临床疗效,并探讨其作用机制。方法:120例咳嗽变异性哮喘患者采用随机对照的原则分为观察组、三伏灸组和肠内营养组,每组各40例。三伏灸组给予三伏灸治疗,肠内营养组给予肠内营养治疗,观察组给予肠内营养配合三伏灸治疗。治疗1个疗程后,比较两组患者临床疗效、症状积分、肺功能[第1秒用力呼气量(forced expiratory volume in first second,FEV1)、呼气峰流速值(peak expiratory flow,PEF)]。结果:观察组有效率为95.0%,三伏灸组有效率为85.0%,肠内营养组有效率为77.5%,观察组明显优于三伏灸组和肠内营养组,差异均有统计学意义(P<0.05)。观察组症状总积分、PEF、FEV1、CD3^+、CD4^+、CD4^+/CD8^+、CD8^+、血红蛋白、血清总蛋白、血清蛋白、体质量、肱三头肌皮皱厚度和上臂肌围,优于三伏灸组和肠内营养组,差异有统计学意义(P<0.05)。结论:三伏灸配合肠内营养能明显改善小儿CVA患者的肺功能和临床症状,可能通过调节细胞免疫,提高患者的血红蛋白、血清总蛋白、血清蛋白、体质量、肱三头肌皮皱厚度和上臂肌围等营养状况等机制作用,从而提高临床疗效。

Objective：To observe the dog day moxibustion enteral nutrition for children CVA clinical efficacy,and to explore its mechanism.Methods：A total of 120 met the inclusion criteria of cases of cough variant asthma patients,the principle of the use of randomized into the treatment group,dog day moxibustion group and enteral nutrition group,each with 40 cases,dog day moxibustion group were given dog day moxibustion therapy,intestinal within nutrition group were given enteral nutrition,enteral nutrition therapy group with the dog day moxibustion treatment,after a course of treatment,efficacy evaluation.Results：The cure rate of37.5%,total effective rate was 95.0%;dog day moxibustion group cure rate was 30.0%,the total effective rate was 85.0%;enteral nutrition group,the cure rate was 12.5%,total effective rate was 77.5%,treatment group than the dog day moxibustion group and enteral nutrition group,the differences were statistically significant（P〈0.05）.In total score of symptoms,PEF,FEV1,CD3^＋,CD4^＋,CD4^＋/CD8^＋and CD8^＋,Hb,the TP,ALB,body weight,triceps skin fold thickness and arm muscle circumference,the treatment group than the dog day moxibustion group and intestines within the nutrition group,the difference was statistically significant（P〈0.05）.Conclusion：The dog day moxibustion with enteral nutrition can improve lung function and symptoms in children with CVA patients by regulating cell-mediated immunity,increase Hb,TP,ALB,the patient＇s body weight,triceps skin fold thickness and arm muscle circumference mechanisms such as the role of nutritional status,and improve clinical efficacy.