深圳女性子宫颈人乳头瘤病毒感染型别分布情况

Cervical human papillomavirus type-distribution among women in Shenzhen

目的了解深圳市女性子宫颈人乳头瘤病毒(human papillomavirus, HPV)感染及基因亚型分布情况。方法以深圳地区2017年1—9月参与子宫颈癌HPV筛查女性为研究对象,分析其中结果阳性并进行HPV基因分型检测的女性HPV感染亚型分布,采用χ~2检验和Fisher确切概率法进行组间比较。结果 2017年1—9月,深圳地区参与子宫颈癌筛查的妇女HPV感染率为10.3%(10 328/100 222),其中5 258例HPV感染者纳入型别分布分析,中位年龄为36岁(P25～P75:31～44),汉族占99.6%(5 238例),已婚者占96.8%(5 090例),单一型别感染者占78.7%(4 139例),高危型HPV感染者占94.3%(4 960例)。在4 960例高危型HPV感染者中,HPV52、HPV16、HPV58、HPV51和HPV18为感染最多前5种亚型,分别占26.1%、17.4%、14.7%、8.9%和8.4%。在298例低危型HPV感染者中,HPV6、HPV43、HPV11、HPV42和HPV44为感染最多前5种亚型,分别占30.5%、20.8%、20.1%、20.1%和11.7%。高危型HPV感染率在不同年龄、民族、婚姻状况、职业、筛查形式和医保类型的HPV阳性者的分布差异均无统计学意义(P>0.05)。结论深圳地区女性子宫颈HPV感染以单一型为主,HPV52是最常见的高危感染亚型。

Objective To explore the cervical human papillomavirus（HPV）prevalence and its genotype distribution among Shenzhen women.Methods Women who participated in HPV screening for cervical cancer between January and September,2017 were observed.Chi-square tests and Fisher exact probability tests were used for analyzing HPV distribution among different subgroups of women.Results HPV prevalence for women including in cervical cancer screening in Shenzhen was 10.3%（10 328/100 222）between January and September,2017.Among 5 258 women who received HPV genotyping,the median age was 36 years oldthe proportions of Han nationality,married status,and single-type HPV infection were 99.6%（5 238 cases）,96.8%（5 090）,and 78.7%（4 139）.In addition,there were 4 960（94.3%）women infected by high risk HPV and 298（5.7%）women infected by low risk HPV.The most common high risk HPV genotypes were HPV52（26.1%）,followed by HPV16（17.4%）,HPV58（14.7%）,HPV51（8.9%）,and HPV18（8.4%）.The most common low risk HPV genotypes were HPV6（30.5%）,followed by HPV43（20.8%）,HPV11（20.1%）,HPV42（20.1%）,and HPV44（11.7%）.The distributions of high risk HPV infection did not vary significantly when stratified by age,nationality,marital status,occupation,screening types and medical insurances（P〉0.05）.Conclusion Single-type HPV infection was the main form for women infected by HPV in Shenzhen area,in which HPV52 was the most common HPV genotypes.