奥卡西平治疗部分癫痫发作的临床效果及对患者脑电图的影响

Clinical effect of oxcarbazepine on patients with partial seizures and its effect on EEG

目的探讨奥卡西平治疗部分癫痫发作患者的临床效果及对患者脑电图的影响。方法选取2016年1月至2018年1月成人部分性癫痫发作的患者160例作为研究对象,按照随机数字表法分为A组和B组,每组80例。A组患者采用左乙拉西坦治疗,B组患者采用奥卡西平治疗;观察两组患者的临床疗效,认知功能改变及对脑电图的影响。结果与A组患者相比,B组患者的临床疗效改善(P <0. 05),痫样放电频率显著减少(P <0. 05);治疗后,两组患者语言智商评分均有所增加(P <0. 05),但两组间评分比较差异未见统计学意义(P> 0. 05)。结论奥卡西平治疗部分性癫痫发作的临床效果良好,对认知功能有一定的改善作用,且能够减少患者痫样放电的频率。

Objective To investigate the clinical effect of oxcarbazepine on patients with partial seizures and its effect on EEG. Methods A total of 160 cases of adult partial epileptic seizures in our hospital in January 2016 to January 2018 were selected as the research subjects. According to the random digital table method,the patients were divided into group A and group B,with 80 cases in each group;the patients in group A were treated with levetiracetam,and group B was treated with oxcarbazepine; the clinical efficacy and cognitive function of the two groups were observed. Results Compared with the A group,the clinical efficacy of the B group was significantly improved（ P〈0. 05）,and the frequency of epileptiform discharge was significantly reduced（ P〈0. 05）. After treatment,the VIQ scores of the two groups were significantly increased（ P〈0. 05）,but there was no significant difference between the two groups（ P〉0. 05）. Conclusions The clinical effect of oxcarbazepine on partial epileptic seizures is good,it can improve the cognitive function and significantly reduce the frequency of epileptic discharge.