化疗联合四逆汤对C57BL/6小鼠Lewis肺癌生长的影响

Effects of chemotherapy with Sini decoction on the growth of Lewis lung cancer in C57BL/6 mice

目的观察化疗联用不同剂量四逆汤对Lewis肺癌生长的影响。方法建立C57BL/6小鼠Lewis肺癌模型,随机分为6组,每组16只:空白对照组、环磷酰胺(cyclophosphamide,CTX)组、四逆汤组、化疗联合高剂量四逆汤组、化疗联合中剂量四逆汤组、化疗联合低剂量四逆汤组,连续灌胃给药21天。随机抽取各组10只于第21天处死小鼠,观察各组抑瘤作用,6只观察生存期。结果化疗联合应用四逆汤可抑制Lewis肺癌生长(P <0. 05),联用中、低剂量四逆汤时抑瘤率优于纯化疗组(P <0. 05),联用中剂量四逆汤时生存期最长(P <0. 05)。结论化疗联合应用中剂量四逆汤对治疗Lewis肺癌可能有较好的辅助作用。

Objective To observe the effects of chemotherapy with different doses of Sini decoction on the growth of Lewis lung cancer. Methods The Lewis lung cancer model of C57BL/6 mice was established and randomly divided into blank control group, cyclophosphamide （CTX） group, Sini decoction group, chemotherapy with high, middle, low dose Sini decoction group, with 16 mice in each group, a total of 6 groups, for 21 days continuous intragastric administration. Ten mice in each group were randomly selected and sacrificed on the 21 st day to observe the anti-tumor effect of each group, and overall survival of the remaining 6 was observed. Results Chemotherapy combined with Sini decoction could inhibit the growth of Lewis lung cancer （ P 〈0.05）. The anti-tumor rate of chemotherapy with middle and low dose Sini decoction groups was higher than the blank group （ P 〈0.05）. When chemotherapy combined with middle dose Sini decoction, the overall survival period was the longest （ P 〈0.05）. Conclusion The combination of chemotherapy and middle dose Sini decoction may have a good auxiliary effect on treating Lewis lung cancer.