血塞通联合西药治疗AMI急诊PCI术后疗效及对患者心功能指标和炎症因子影响的研究

Effects of Xuesaitong injection combined with western medicine on heart function and inflammatory factor of AMI patients after PCI

目的:研究血塞通注射液联合西药治疗急性心肌梗死(AMI)急诊PCI术后的效果及对患者心功能指标和炎性因子的影响。方法:选择因突发AMI入院治疗的患者124例,随机分为血塞通组和常规组,常规组患者使用标准治疗方法,血塞通组在常规组治疗的基础上,术后进行血塞通注射液静脉滴注治疗。测定两组患者治疗前和治疗后LVEF、BNP及LVEDD的变化。测定两组患者治疗前和术后1周时的CTnT、CKMB、TNF-α、IL-6、IL-8、hs-CRP和PTX-3水平的变化,并对两组患者治疗后的疗效进行评价。结果:治疗后常规组与血塞通组的心功能和心肌梗死标志物水平均显著降低(P<0.05),血塞通组变化更大(P<0.05);常规组与血塞通组的炎症因子水平显著降低(P<0.05),血塞通组变化更大(P<0.05)。治疗过程中,常规组出现2例心动过速,1例血压升高,3例恶心呕吐,不良反应率9.67%。血塞通组出现2例术后面色潮红,1例轻度耳鸣,2例心动过速,不良反应率8.06%,两组患者之间的不良反应率无统计学意义(P>0.05)。血塞通组的治疗有效率显著高于常规组(P<0.05)。结论:血塞通注射液能够有效的改善AMI患者的心功能,降低心肌梗死标志物和体内炎症因子的水平,且治疗有效率高,不良反应少。

Objective： The effects of Xuesaitong injection combined with western medicine on heart function and inflammatory factor of AMI patients after PCI was studied. Methods：124 patients with AMI were selected, and radomly divided into Xuesaitong group and control group. The patients in the control group were treated with standard therapy, and the Xuesaitong group were treated with intravenous infusion of Xuesaitong injection on the basis of control group. Changes in LVEF, BNP, LVEDD, CTnT, CKMB, TNF-α, IL-6, IL-8, hs-CRP和PTX-3 were measured before and after treatment in both groups of patients, the efficacy of the two groups after treatment was evaluated. Results： After treatment, the heart function and myocardial infarction markers in the control group and the Xuesaitong group was significantly decreased （ P 〈0.05）, among which, the Xuesaitong group had a greater change （ P 〈0.05）.The levels of inflammatory factors in the conventional group and Xuesaitong group were significantly lower （ P 〈0.05）, among which, the Xuesaitong group had greater change （ P 〈0.05）. During the course of treatment, 2 patients had tachycardia, 1 had elevated blood pressure, and 3 had nausea and vomiting. The adverse reaction rate was 9.67%. In the Xuesaitong group, there were 2 cases of postoperative facial flushing, 1 case of mild tinnitus, and 2 cases of tachycardia. The adverse reaction rate in Xuesaitong group was 8.06%. The adverse reaction rate between the two groups of patients was not statistically significant （ P 〉0.05）.The treatment efficiency of Xuesaitong group was significantly higher than that of the routine group （ P 〈0.05）. Conclusion： Xuesaitong injection can effectively improve the cardiac function of AMI patients, reduce the level of myocardial infarction markers and inflammatory factors , has high treatment efficiency and fewer adverse reactions, which is worthy of being popularized and applied in clinical practice.