生脉散合丹参饮联合西药治疗慢性心力衰竭疗效研究

Observation of the clinical effect of Shengmai San combined Danshen Yin allied western medicine therapy on chronic heart failure therapy

目的:观察生脉散合丹参饮加西医常规疗法治疗慢性心力衰竭的疗效。方法:将60例慢性心力衰竭患者随机分为两组。对照组采用常规西医治疗,治疗组在基本西医治疗的基础上加用生脉散合丹参饮,疗程为2周。观察两组治疗前后临床症状、左室射血分数(LVEF)、血浆脑利钠肽(BNP)、内皮素-1(ET-1)和6分钟步行试验步行距离(6MWT)的变化。结果:治疗组患者中17例显效,11例有效,2例无效,治疗总有效率为93.33%。对照组患者中11例显效,12例有效,7例无效,治疗总有效率为76.67%,两组差异显著(P <0.05)。两组治疗后LVEF、BNP、ET-1、6MWT均有改善,治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。结论:西医治疗基础上加用生脉散合丹参饮治疗慢性心力衰竭的临床疗效优于单用西医治疗。

Objective： Study to observe the clinical effect of Shenmai San combined Danshen Yin allied western medicine therapy on chronic heart failure. Method： 60 patients of chronic heart failure were randomly assigned to the treat group（group T）or to the control group（group C）.Group C was treated by routine western medicine. Group T was treated by Chinese herb decoction（Shenmai San combined Danshen Yin）besides the treatment of group C. Observation period was 2 weeks.Symptoms,LVEF, BNP, ET-1, 6 min walking distance to walk test were observed. Results： The patients in the treat group,17 showed significant effect,11 were effective,2 were ineffective,and the total effective rate was 93.33%.In the control group,11 showed significant effect,12 were effective,7 were ineffective, and the total effective rate was 76.67%,and the diffirence between the two groups was significant. After treatment, the two groups of LVEF,BNP,ET-1,6 MWT have been improved, there were significant differences in the treat group compared with the control group. Conclusions： According to the result ,the group T was better than the group C, which was treated by Chinese herb Decoction（Shenmai San combined Danshen Yin）besides the treatment of routine western medicine.