疏肝理气解郁汤治疗抑郁症临床疗效研究

Efficacy of Shugan Liqi Jieyu decoction for treating depressed patients and its clinical symptoms

目的:对比分析疏肝理气之解郁汤用于抑郁症患者治疗的疗效及对其临床症状影响。方法:对本院确诊并接受治疗的100例抑郁症患者展开研究,按照治疗方案分为对照组(50例)与研究组(50例),对照组接受盐酸氟西汀胶囊治疗,研究组接受中药解郁汤治疗,连续用药治疗2个月。统计两组患者临床疗效,并利用HAMD表与SDS表、《中医证候等级评估量表》对两组患者治疗前后抑郁程度、精神状况、躯体症状进行评估。结果:研究组患者临床疗效92.00%虽略高于对照组82.00%,但差异无统计学意义(χ~2=2.210,P>0.05);与治疗前比较,两组患者HAMD评分与SDS评分以及各症状表现得分均显著下降,但治疗后组间比较发现两组患者HAMD评分、SDS评分、精神抑郁、腹胀嗳气、失眠多梦评分均无统计学差异。研究组患者神疲乏力、胸闷心烦、大便秘结以及不思饮食得分均显著比对照组更低,胸闷心烦(1.63±0.73)分vs(1.93±0.75)分(P<0.05);神疲乏力为(1.59±0.65)分vs(1.84±0.81)分(P<0.05);大便秘结(1.51±0.63)分vs(1.89±0.98)分(P<0.05);不思饮食(1.51±1.01)分vs(2.05±1.21)分(P<0.05)。结论:解郁汤在抑郁症治疗中疗效较可靠,服用安全,无明显药物不良反应。

Objective： To compare and analyze the therapeutic effect of Shugan Liqi Jieyu decoction for treating depression patients and its clinical symptoms. Methods： A total of 100 patients with depression diagnosed and treated in our hospital were divided into control group （50 cases） and study group （50 cases） according to the treatment plan. The control group received fluoxetine hydrochloride Ting capsule treatment, the study group received traditional Chinese medicine Shugan Liqi Jieyu decoction treatment, continuous medication for 2 months. The clinical efficacy of the two groups were statistically analyzed. The depression, mental status and somatic symptoms of both groups were evaluated before and after treatment by using the HAMD and SDS tables and TCM syndrome rating Scale. Results： The clinical efficacy 92.00% of the study group was slightly higher than that of the control group 82.00%, but the difference was not statistically significant （χ 2 =2.210, P 〉0.05）. Compared with before treatment, the HAMD score and SDS score and the scores of each symptom were significantly decreased in the two groups. However, after treatment, the HAMD score, SDS score, mental depression, bloating, suffocation, and insomnia scores were not found in the two groups. The study group patients with fatigue, chest tightness, discomfort, constipation and diet scores were significantly lower than the control group thoracic chest upset（1.63±0.73）points vs （1.93±0.75）points（ P 〈0.05）. God Weakness （1.59±0.65）points vs （1.84±0.81）points（ P 〈0.05）.Constipation（1.51±0.63）points vs （1.89±0.98）points（ P 〈0.05）.Do not think diet（1.51±.01）points vs （2.05±1.21）points（ P 〈0.05）, the difference was significant. The incidence of adverse reactions （0.00%） in the study group was significantly lower than that in the control group （18.00%）, and the difference was significant （ P 〈0.05）.Conclusion： Shugan Liqi Jieyu decoction in the treatment of depression, the exact effect of reliable, safe to take, no obvious adverse drug reactions, with high clinical value.