硫酸镁联合血压平颗粒治疗妊娠高血压患者的临床疗效及对血清LIF Apelin β-HCG的影响

Clinical Efficacy of of Magnesium Sulfate Combined with Xueyaping Granules on Pregnancy-induced Hypertension and Effects on the levels of LIF,Apelin and Beta-HCG in Serum

目的:评估硫酸镁联合血压平颗粒在治疗妊娠高血压(pregnancy-induced hypertension,PIH)时的临床疗效,及其对血清白血病抑制因子(leukemia inhibitory Factor,LIF)、爱帕琳肽(Apelin)和β绒毛膜促性腺激素(β-Chorionic Gonadotropin,β-HCG)水平的影响。方法:本实验选取我院2015年12月至2016年12月收治的患者中符合标准的90例PIH病患为研究对象,随机分为对照组及实验组,每组45例。对照组45例予硫酸镁静脉滴注联合盐酸拉贝洛尔片口服治疗,实验组45例予硫酸镁静脉滴注联合血压平颗粒口服治疗。比较两组临床疗效,血清LIF、Apelin、β-HCG水平变化,观察两组患者治疗前后收缩压和舒张压变化情况,及不同治疗组的妊娠结局。结果:实验组总有效率(88.89%)高于对照组(64.44%),差异有统计学意义(P<0.05)。两组血清指标比较,治疗前LIF、Apelin、β-HCG水平无明显差异(P>0.05);治疗后LIF水平均显著上升,且实验组上升水平高于对照组[(752.38±31.57) VS(703.01±32.02)],差异有统计学意义(P<0.05); Apelin、β-HCG水平均显著下降,且实验组下降水平高于对照组[(233.33±23.56) VS(271.69±24.83)、(15772.96±1705.93) VS(11473.19±1698.87)],差异有统计学意义(P<0.05)。治疗前,收缩压、舒张压无明显差异(P>0.05);治疗后收缩压、舒张压均下降,且实验组下降程度高于正常组[(135.8±6.9) VS(153.1±8.7)、(88.0±5.8) VS(92.97±5.7)],差异有统计学意义(P<0.05)。两组妊娠结局比较,自然分娩率实验组(77.78%)显著高于对照组(35.56%),差异有统计学意义(P<0.05)。结论:血压平颗粒联合硫酸镁治疗对PIH患者的效果肯定,能够升高血清LIF水平,降低血清Apelin及β-HCG水平,降低血压水平及改善妊娠结局。

Objective： To evaluate the clinical efficacy of magnesium sulfate combined with Xueyapinggranules in the treatment of pregnancy-induced hypertension （PIH）, and the effect on serum leukemia inhibitory factor （LIF） Apelin and β-chorionic gonadotropin （β-HCG） levels. Methods： 90 patients with PIHwere enrolled of our hospital from December 2015 to December 2016. They were randomly divided into controlgroup and experimental group （n = 45）. In the control group, 45 cases were treated with intravenous infusionof magnesium sulfate and lapelol hydrochloride tablets. 45 cases in the experimental group were treated withXueyaping granules. Changes of serum LIF, Apelin and β-HCG levels were compared between the two groups.Changes of systolic and diastolic blood pressure before and after treatment were observed, and the pregnancyoutcomes of different treatment groups were observed. Results： The total effective rate （88.89%） in the experimental group was higher than that in the control group （64.44%）, the difference was statistically significant（P〈0.05）. There was no significant difference in LIF, Apelin and β-HCG levels between the two groups （P〉0.05）. After treatment, the levels of LIF were significantly increased, and the level of LIF, Apelin and β-HCG was significantly higher than that of the control group （752.38 ± 31.57 VS 703.01±32.02 （P 〈0.05）.Apelin and β-HCG levels were significantly decreased, and the level of the experimental group was lower thanthat of the control group （233.33 ± 23.56 VS 271.69 ± 24.83）, the difference was statistically significant （P〈0.05） （15772.96 ± 1705.93） VS （11473.19 ± 1698.87）], the difference was statistically significant （P〈0.05）. The systolic and diastolic blood pressure of the experimental group were lower than those of the normalgroup （135.8 ± 6.9） VS （153.1 ± 8.7）, and the systolic and diastolic blood pressure （88.0 ± 5.8） VS （92.97 ± 5.7）], the difference was statistically significant （ P 〈 0. 05）. Compared with the control group （ 35.56%）, the difference between the two groups was statistically significant （P〈0.05）. Conclusion： Xueyapinggranule combined with Magnesium Sulfate treatment for patients with PIH certain effect, can increase the levelof LIF, serum Apelin and beta -HCG level, reduce the level of blood pressure and improve the outcome ofpregnancy.