左氧氟沙星联合抗结核化疗方案治疗复治涂阳肺结核的临床研究

Clinical study levofloxacin combined with anti-tuberculosis chemotherapy in the treatment of recurrent smear-positive pulmonary tuberculosis

目的:探讨左氧氟沙星联合抗结核化疗方案治疗复治涂阳肺结核的临床效果。方法:选择2016年6月-2017年6月复治涂阳肺结核患者90例根据治疗方法分组。对照组给予单一抗结核化疗方案治疗,观察组则给予抗结核化疗方案联合左氧氟沙星治疗。比较两组复治涂阳肺结核控制率;痰菌转阴的时间、空洞闭合时间、肺病灶吸收时间;治疗前后患者生活质量WHO-100评分;药物不良反应率。结果:观察组复治涂阳肺结核控制率高于对照组,P <0.05;观察组痰菌转阴的时间、空洞闭合时间、肺病灶吸收时间短于对照组,P <0.05;治疗前两组生活质量WHO-100评分相近,P> 0.05;治疗后观察组生活质量WHO-100评分优于对照组,P <0.05。观察组药物不良反应率和对照组无明显差异,P> 0.05。结论:抗结核化疗方案联合左氧氟沙星治疗复治涂阳肺结核的应用效果确切,可有效促进痰菌转阴和病灶吸收,改善生活质量,且无严重不良反应,安全有效,值得推广应用。

Objective To explore the effect of levofloxacin combined with anti-tuberculosis chemotherapy in the treatment of recurrent smear-positive pulmonary tuberculosis. Methods： A total of 90 cases of patients with recurrent smear-positive pulmonary tuberculosis from June 2016 to June 2017 were selected according to the treatment method. The control group was treated with a single anti-tuberculous chemotherapy regimen, while the observation group was treated with an anti-tuberculous chemotherapy regimen combined with levofoxacin. The control rate of re-treatment of smear-positive pulmonary tuberculosis was compared between the two groups. The time of phlegm bacteria turning negative, the time of cavity closing, and the time of lung focus absorption; WHO-100 score of quality of life before and after treatment, the adverse drug reaction rate were compared. Results： The control rate of the observation group was higher than that of the control group, P 〈 0.05. In the observation group, the time of sputum negative transformation, cavity closure time and lung focus absorption time were shorter than those of the control group, P 〈 0.05. The scores of WHO-100 were similar in the two groups before treatment, P 〉 0.05. The quality of life of the observation group was better than that of the control group, P 〈 0.05. There was no signifcant difference in adverse drug reaction rate between the observation group and the control group, P 〉 0.05. Conclusion： Anti-tuberculous chemotherapy combined with levofloxacin had a definite application effect in the treatment of recurrent smear-positive pulmonary tuberculosis, it could efectively promote the transformation of sputum bacteria to become negative and the absorption of lesions, and improve the quality of life without serious adverse reactions.