摘要
组织工程气道重建是利用原生、异体或人工合成等不同的材料,结合种子细胞及生长因子,修复缺损气道并恢复其生理功能的气管替代治疗方法。而移植物支架的选择是影响气道重建成功与否的关键所在。通过改善移植物支架性能,使其拥有与天然气管相似的机械特性与生物相容性,并促进其血管化和再上皮化,降低免疫原性,进而完成气道重建。本文旨在就气道重建中移植物支架的研究进展作一综述。
Tissue-engineering airway reconstruction is a tracheal replacement therapy, which uses different materials, such as primary, allogeneie or synthetic, combined with seed cells and growth factors to repair the defect airway and restore its physiological function. The choice of stent graft is the key to the success or failure of airway reconstruction. By improving the performance of graft scaffolds, it has similar mechanical properties and biocompatibility with natural gas tubes, promoting vascularization and re- epithelization, reducing immunogenicity and completing airway reconstruction. This article aims to review advances in the study of graft scaffolds for airway remodeling.
作者
仲毅
潘枢
章方彪
史宏灿
Zhong Yi;Pan Shu;Zhang Fangbiao;Shi Hongcan(Department of Cardiothoracic Surgery,Clinical College of Yangzhou University,Yangzhou 225000,China)
出处
《国际外科学杂志》
2018年第11期769-773,共5页
International Journal of Surgery
基金
国家自然科学基金(81770018)
浙江省医药卫生科技计划项目(2016KYB336)
关键词
气管
支架
再生医学
组织工程
Trachea
Stents
Regenerative medicine
Tissue engineering