不同时点加用加味香砂六君子汤联合四联疗法治疗幽门螺杆菌感染的疗效比较

Clinical efficacy of the Xiangsha Liujunzi decoction plus quadruple regimen on infection of Hp at different points

目的:观察不同时点加用加味香砂六君子汤联合四联疗法治疗幽门螺杆菌(Hp)感染患者的临床疗效。方法:幽门螺杆菌感染患者122例随机分为单纯西药组40例、西药前服用中药组41例和西药同时服用中药组41例。单纯西药组采用西药标准四联疗法:埃索美拉唑镁肠溶片20mg,2次/d,阿莫西林分散片1.0g,2次/d,克拉霉素分散片500mg,2次/d,枸橼酸铋钾胶囊0.22g,2次/d,疗程14d。西药前服用中药组在单纯西药组治疗的基础上,于西药服药前14d口服加味香砂六君子汤,1剂/d,疗程14d。观察三组患者的Hp根除率,治疗前后计算三组患者的中医证候积分,评价临床疗效。结果:西药同时服用中药组Hp根除率为90.24%,西药前服用中药组Hp根除率为73.17%,西药组Hp根除率为67.50%,西药同时服用中药组Hp根除率优于其他两组(P <0.05);西药同时服用中药组总有效率为92.68%,西药前服用中药组总有效率为75.61%,西药组总有效率为52.50%,西药同时服用中药组总有效率优于其他两组(P <0.05);治疗后西药同时服用中药组中医症状的改善优于其他两组(P <0.05)。结论:四联疗法同时服用加味香砂六君子汤可以提高幽门螺杆菌的根除率和临床有效率,有效改善患者的临床症状。

Objective： To observe clinical efects of the Xiangsha Liujunzi decoction （ 香砂六君子汤 ） plus quadruple regimen on H. pylori at diferent points. Methods： 122 patients with infection of Hp were randomly divided into three groups. The frst group （40 cases） was given western medicine （quadruple regimen）. The second group （41 cases） was given TCM medicine （the Xiangsha Liujunzi decoction） before taking western medicine. The third group （41 cases） was given TCM medicine and western medicine at the same time. Results： Hp eradication rate in the third group （67.5%） was better than the frst group （90.24%） and the second group （73.17%）. The total efective rate was 92.68% in the third group, higher than 52.5% in the frst group and 75.61% in the second group （P〈0.05）. The improvement of symptoms in the third group was better than the other groups （P〈0.05）. Conclusion： The Xiangsha Liujunzi decoction plus quadruple regimen can improve Hp eradication rate and the total efective rate, and efectively improve the clinical symptoms of patients.