“足缓难行刺冲阳”脑效应机制功能磁共振成像研究

Functional magnetic resonance imaging study of brain effect mechanism of "acupuncture at Chongyang acupoint for the treatment of walking slowly and difficulty"

目的通过针刺正常健康志愿者右侧冲阳穴,观察脑内的激活区和抑制区,从而探讨"足缓难行刺冲阳"的脑效应机制。材料与方法应用3.0 T磁共振扫描采集16名健康志愿者针刺右侧冲阳穴数据,并进行数据处理与统计分析。结果针刺冲阳穴引起的正激活脑区为:左侧小脑前叶、小脑后叶、额叶中央前回、颞上回(BA42)、颞横回(BA41)、颞中回、顶叶中央后回、外核、豆状核、外侧苍白球;右侧小脑后叶、额叶中央前回(BA6)、额中回(BA10)、额下回、颞横回、颞中回、顶叶中央后回(BA3)、顶下小叶、扣带回(BA24)、脑岛、丘脑;负激活脑区:左侧枕上回、后扣带回(BA30)、楔前叶、颞中回;右侧海马、外核。结论针刺冲阳穴产生的针刺效应与大脑中枢关系密切,针刺信息可以直接影响"疼痛矩阵"而减轻疼痛,可能与正激活丘脑影响疼痛信息的传导,和负激活边缘系统抑制主观感受的情绪反应有关。

Objective： To observe the activation and inhibitory areas in the brain by acupuncture normal healthy volunteers, and to explore the brain effect mechanism of ＂acupuncture at Chongyang point for the treatment of walking slowly and difficulty＂. Materials and Methods： Using the 3.0 T MR scan, 16 healthy volunteers were collected and the data were processed and statistically analyzed. Materials and Methods： Using the 3.0 T MR scan, 16 healthy volunteers were collected and the data were processed and statistically analyzed. Results： Acupuncture at Chongyang point positive activation area： the left cerebellum anterior lobe, cerebellum posterior lobe, center prefrontal gyrus of frontal lobes, superior temporal gyms （BA42）, temporal transverse back （BA41）, middle temporal gyrus, parietal lobe, outer core, lentiform nucleus, the lateral pallidum, the right cerebellum posterior lobe, forehead prefrontal （BA6）, middle frontal gyrus （BA10）, inferior frontal gyms, gyri temporales txansversi, gyri temporalis mediium, posterior central gyrus of parietal lobe （BA3）, inferior parietal lobule, cingulate gyrus （BA24）, insula, thalamus. Negative activation area： the left occipital, posterior cingulate （BA30）, precuneus, temporal gyms, the right hippocampus, outer core. Conclusions： Acupuncture Chongyang closely associated with brain center of acupuncture effect, acupuncture information can directly affect the ＂pain matrix＂ reduce analgesic effect, pass though the effect of positive activation of thalamus on the conduction of pain information, and negative activated limbic system restrain subjective feelings of emotional response to alleviate the pain.