骨骼肌脂肪量化的影像学评价及其在2型糖尿病中的临床价值研究

Image evaluation of skeletal muscle fat quantification and its clinical value in type 2 diabetes mellitus

近年来,随着影像技术的发展,对于骨骼肌脂肪含量的测定日渐准确。机体脂肪被认为是胰岛素的主要靶器官之一,其含量与胰岛素抵抗之间存在着紧密的联系,其中,骨骼肌脂肪的异位沉积及异常代谢是胰岛素抵抗发病机制的重要因素之一。2型糖尿病是世界上最常见的非传染性疾病之一,其发病率正在逐步增加,特别是在发展中国家。目前认为,胰岛素抵抗(insulin resistance,IR)是2型糖尿病的主要发病机制,故骨骼肌脂肪含量与胰岛素抵抗相关性的临床价值研究显得尤为重要,通过影像评价骨骼肌脂肪含量,研究其与胰岛素抵抗的相关性,对糖尿病患者的运动、生活习惯以及治疗有着至关重要的指导作用。

In recent years, with the advancement of imaging technology, the determination of skeletal muscle fat content has become increasingly accurate. Body fat is considered to be a main target organ of insulin, and body fat composition is closely associated with insulin resistance. In particular, ectopic deposition and abnormal metabolism of skeletal muscle fat are one of the important factors in the pathogenesis of insulin resistance. Type 2 diabetes is one of the most common non communicable diseases in the world with alarmingly high incidence globally, especially in developing countries. At present, insulin resistance （IR） is considered to be the main pathogenesis of type 2 diabetes. Therefore, the clinical value of the correlation between skeletal muscle fat content and insulin resistance is particularly critical. Image evaluation of skeletal muscle fat content and the study of its association with insulin resistance play a crucial role in the management and treatment of diabetes such as physical activity, life style modification, and medication.