栓塞微球在肝动脉化疗栓塞治疗乏血供肝癌中的临床应用效果

Clinical application of embolized microspheres in hepatic artery chemoembolization in the treatment of liver cancer with lack of blood supply

目的探讨栓塞微球在肝动脉化疗栓塞术(TACE)治疗乏血供肝癌患者的临床应用效果。方法选取2015年1月~2016年1月我院收治的54例原发性乏血供肝癌患者作为研究对象,采用随机数字表法将其分为实验组与对照组,每组各27例。两组患者均采用TACE术治疗,对照组患者采用碘化油联合明胶海绵作为栓塞剂,实验组患者则采用碘化油联合栓塞微球栓塞。比较两组患者肝癌的近期疗效及1年、2年内的生存率。结果实验组患者的治疗总有效率为44.44%,疾病控制率为88.89%,均高于对照组的29.63%、70.37%,差异均有统计学意义(P<0.05)。实验组患者1年和2年内的生存率分别为88.89%、66.67%,高于对照组患者的74.07%、51.85%,差异均有统计学意义(P<0.05)。结论乏血供肝癌患者行TACE术治疗时,选用栓塞微球作为栓塞剂,能获得更好的栓塞效果,提高临床治疗效果,改善患者预后,值得临床进一步研究。

Objective To investigate the clinical effect of embolization microspheres in transcatheter arterial chemoembolization（TACE） for patients with liver cancer with poor blood supply. Methods A total of 54 patients with primary liver cancer from January 2015 to January 2016 were selected as subjects and were divided into experimental group and control group according to the random number table method, with 27 patients in each group. Both groups were treated with TACE. The patients in the control group were embolized with iodized oil combined with gelatin sponge, while the patients in the experimental group were embolized with iodized oil combined with embolization microspheres. The short-term curative effect and 1-year and 2-year survival rate were compared between the two groups. Results The total effective rate and disease control rate of the patients in the experimental group were 44.44% and 88.89% respectively, which were significantly higher than those in the control group of 29.63% and 70.37%, the differences were statistically significant（P〈0.05）. The 1-year and 2-year survival rates of the patients in the experimental group were 88.89%and 66.67%, respectively, which were significantly higher than those in the control group of 74.07% and 51.85%, the differences were statistically significant（P〈0.05）. Conclusion The embolization of microspheres as embolization agent in the treatment of TACE for patients with liver cancer with poor blood supply can obtain better embolization effect, improve the clinical treatment effect and improve the prognosis of the patients, which is worthy of further clinical study.