硫酸镁联合硝苯地平治疗妊娠合并高血压的效果

Effect of Magnesium Sulfate combined with Nifedipine on pregnancy with hypertension

目的研究硫酸镁联合拉贝洛尔、硝苯地平治疗妊娠合并高血压的效果。方法选取2016年1月~2018年3月在我院治疗的94例妊娠合并高血压患者作为研究对象,根据治疗方法的不同分为对照组和研究组,每组各47例。对照组实施硫酸镁联合拉贝洛尔治疗,观察组予以硫酸镁联合硝苯地平治疗。将两组的血压水平、血液动力学、24 h尿蛋白、不良反应发生情况、妊娠结局进行比较。结果观察组治疗后的舒张压、收缩压、血黏度、血细胞比容、24 h尿蛋白水平均低于对照组,差异均有统计学意义(P<0.05);两组的不良反应总发生率比较,差异无统计学意义(P>0.05);观察组的产后出血率、早产率、剖宫产率均低于对照组,差异均有统计学意义(P<0.05),观察组的胎儿窘迫发生率、新生儿窒息发生率低于对照组,差异有统计学意义(P<0.05),两组围生儿死亡比较,率差异无统计学意义(P<0.05)。结论硫酸镁联合硝苯地平用在妊娠合并高血压患者中安全有效,在改善血压水平、血液动力学方面的作用优于硫酸镁联合拉贝洛尔。

Objective To study the effect of Magnesium Sulfate combined with Labe and Nifedipine in the treatment of pregnancy with hypertension. Methods From January 2016 to March 2018, 94 cases of pregnancy complicated with hypertension in our hospital were selected, they were divided into control group and observation group according to the difference of treatment methods, 47 cases in each group. The control group was treated with Magnesium Sulfate combined with Labe and the observation group was treated with Magnesium Sulfate combined with Nifedipine. The blood pressure, 24 hours urine protein, adverse reaction and pregnancy outcome were compared between the two groups.Results The levels of diastolic blood pressure, systolic blood pressure, blood viscosity and 24 hours urine protein in the observation group were lower than those in the control group（P〈0.05）. There was no significant difference in the incidence of adverse reaction between the two groups（P〉0.05）. There was no significant difference in the perinatal mortality between the two groups. The rates of postpartum hemorrhage, preterm delivery and cesarean section in the observation group were lower than those in the control group（P〈0.05）, and the incidence of fetal distress and neonatal asphyxia in the observation group were lower than in the control group, The differences were statistically significant（P〈0.05）. There was no significant difference in the perinatal mortality between the two groups. Conclusion Magnesium Sulfate combined with Nifedipine is safe and effective in improving blood pressure and hemodynamics.