超声引导细针穿刺活检对青少年和青年甲状腺结节的诊断价值

Value of ultrasound guided fine-needle aspiration biopsy in the diagnosis of thyroid nodules in adolescents and young adults

目的:探讨超声引导细针穿刺活检(US-FNAB)对青少年和青年甲状腺结节的诊断价值。方法 :回顾性选择行超声引导甲状腺结节细针穿刺活检的所有年龄≤30岁患者,纳入有手术病理结果的62例患者共70个结节。将超声引导细针穿刺活检细胞学结果与手术病理结果对照分析。结果:70个结节中,细胞学诊断阳性52个,阴性18个,手术病理结果恶性51个,良性19个。以术后病理结果作为金标准,US-FNAB对青少年和青年甲状腺结节诊断的灵敏度、特异度、阳性预测值、阴性预测值和准确率分别为96.1%、84.2%、94.2%、88.9%和92.9%。US-FNAB诊断青少年和青年甲状腺结节的ROC曲线下面积为0.916。结论:US-FNAB对青少年和青年甲状腺结节具有较高的诊断价值。

Objective：To investigate the value of ultrasound guided fine-needle aspiration biopsy（US-FNAB） in the diagnosis of thyroid nodules in adolescents and young adults. Methods ：Integrated clinical data of 62 patients with 70 thyroid nodules who received US-FNAB were analyzed retrospectively. All patients were yonger than 30 yeas old. The cytology were compared with surgical pathological results. Results：Of 70 biopsies, the cytological results were classified as positive for 52 nodules, negative for 18 nodules. Actually 51 malignant and 19 benign nodules were confirmed by surgical pathologies. The surgical pathologies were regarded as the gold standard .The sensitivity, specificity, positive predictive value , negative predictive value and accuracy of US-FNAB in the diagnosis of thyroid nodules in adolescents and young adults were 96.1%、84.2%、94.2%、88.9%和92.9%, respectively. The area under the ROC curve were 0.916. Conclusions：The US-FNAB are effective diagnostic procedures for thyroid nodules in adolescents and young adults.