维药外敷治疗肾虚督寒型强直性脊柱炎患者的临床研究

Clinical Observation on Effects of External Application of Uighur Medicine on Ankylosing Spondylitis of Kidney Deficiency Type

目的观察莳萝子顽痹散外敷对肾虚督寒型强直性脊柱炎(AS)的临床疗效。方法莳萝子顽痹散治疗组(57例)进行骶髂关节外敷治疗,奇正消痛贴对照组(49例)进行骶髂关节外贴治疗,柳氮磺吡啶片空白组(50例)进行口服治疗。7 d为1疗程,4个疗程后观察AS患者治疗前后各项疗效评价参数及活动性指标变化。结果莳萝子顽痹散外敷可改善AS患者肾虚督寒证候及体征,有效降低AS疾病活动指数(BASDAI)、AS功能指数(BASFI),缩小枕墙距及指地距,改善胸廓活动度、脊柱活动度,降低ESR、CRP(P <0.05);治疗组与对照组疗效相当(P> 0.05)。结论莳萝子顽痹散外敷中西医结合治疗肾虚督寒型AS疗效优于单用西药,与奇正消痛贴疗效相当,但其花费低,且不良反应发生率小,安全性高。

Objective： To explore the clinical efficacy of applicating Shiluozi Wanbi Decoction external on kidney deficiency and cold syndrome type ankylosing spondylitis（AS）. Methods： The treatment group（57 cases）were treated with Shiluozi Wanbi Decoction;the comparison group（49 cases） were treated with Qizheng Xiaotong Plaster,and the blank group（50 cases） only took Sulfasalazine Tablets orally. One treatment course was 7 days.The evaluation parameters and activity indicators were observed before and after treatment after 4 courses. Results： After treatment,compared with the blank group,the external application of Shiluozi Wanbi Decoction could improve the symptoms and signs in kidney deficiency and cold syndrome type AS patients,and effectively reduce the AS disease activity index（BASDAI）,AS function index（BASFI）,reduce the distance between the pillow-wall and the finger-ground,improve the thoracic activity and spinal activity,and also decrease ESR and CRP（P〈0.05）;its efficacy was equal to that of the comparison group（P〈0.05）. Conclusion： The efficacy of Shiluozi Wanbi Decoction external on ankylosing spondylitis is better than that of Western medicine alone,also equivalent to that of Qizheng Xiaotong Plaster,with lower cost,lower rate of adverse reactions and higher safety.