补肾活血化痰法治疗急性脉络膜前动脉区脑梗死的临床研究

Effect Observation on Yinshen Tongmai Decoction on Anterior Choroidal Artery Territory Stroke

目的观察补肾活血化痰法治疗脉络膜前动脉区脑梗死(肾虚血瘀痰阻证)的临床疗效。方法患者82例随机分为两组,对照组予阿司匹林联合硫酸氢氯吡格雷片治疗;中药组在对照组基础上予以益肾通脉方颗粒治疗。两组均连续治疗14 d。将美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数评分、中医症状积分作为临床疗效的评价指标,并检测血清神经烯醇化酶(NSE)以探讨其治疗脑梗死的可能机制。结果中药组临床总有效率为80.49%,高于对照组的70.73%(P <0.05)。两组患者治疗后NIHSS评分、Barthel指数评分、血清神经元特异性烯醇化酶(NSE)水平、中医症状积分均较治疗前显著改善(P <0.05),且中药组明显优于对照组(P <0.05)。结论补肾活血化痰法治疗脉络膜前动脉区脑梗死(肾虚血瘀痰阻证)安全高效,可明显改善患者中医症状,保护缺血脑组织,降低神经功能缺损,提高日常生活能力,降低致残率。

Objective： To evaluate the efficacy of Yinshen Tongmai Decoction on AChA territory stroke. Methods： 82 patients were randomly divided into the herb group and the control group（n = 41）. The control group was treated with Asprin and Clopidogrel Sulfate Tablets. The herb group was given Yinshen Tongmai Decoction. Both treatment courses was 14 days. NIHSS scores,Barthel index and TCM symptom scores were used as evaluation index of clinical efficacy. NSE was detected to explore the possible mechanism of cerebral infarction treatment. Results： The total effective rate in the herb group（80.49%） was superior to that in control group（70.73%）. After treatment,scores of NIHSS,BI and TCM symptom scores,and serum levels of NSE were improved in both group（P〈0.05）. The herb group was better than the control group（P〈0.05）. Conclusion： Yinshen Tongmai Decoction can effectively reduce neurological deficit,ameliorate motor function and disabilities,and improve daily activities of patients.