肽6A对大鼠血管内皮舒张因子释放的影响

Peptide 6A on the release of endothelium-derived relaxing factor in rat aorta

本实验在离体大鼠主动脉条上,观察纤维蛋白(原)降解产物肽6A灌流对血管反应性及血管组织cGMP含量的影响。实验结果表明肽6A呈剂量依赖地显著扩张离体血管,其作用在去内皮后消失;肽6A还能显著提高离体血管组织cGMP含量,NO合成抑制剂L-NNA可阻断这一作用,NO前体L-精氨酸可逆转L-NNA的效应。结果提示肽6A可以通过促进血管内皮释放内皮舒张因子而扩张血管。

An endothelium-derived relaxing factor (EDRF) induced by peptide 6A was investigated with its influence on vasoreactivity and cGMP content of isolated perfused aorta observed. It was found that P 6A significantly relaxed the isolated aortic ring in a dose-dependent manner while the vasodilation action disappeared in denuded vessel. In the meantime P 6A markedly increased the aorta cGMP content which was blocked by NO sythesis inhibitor L-NNA. This blocking action could be reversed by L-arginine, a precursor of NO. P 6A was believed to dilate vessels by stimulating the release of EDRF from endothelium.