国内外感染伤口细菌生物膜处理方式的研究进展

Advances in the Treatment of Bacterial Biofilm in Infected Wound at Home and Abroad

细菌生物膜是感染伤口迁延不愈,手术及局部给药治疗效果不佳的主要原因之一。目前临床上普遍使用的处理伤口细菌生物膜的方法有局部机械清创法、负压疗法、局部药物等,虽具有一定的治疗效果,但细菌生物膜仍是目前临床治疗慢性感染的棘手问题。近年来,国内外学者提出了一些新的治疗方法及理念,如光动力学治疗、低能量光疗、乙酸及抗菌肽等的使用,本文综述了国内外感染伤口细菌生物膜处理的研究进展,以期为目前生物膜的临床治疗与护理带来启发。

Bacterial biofilm is one of the main reasons for the unhealing of infection wound, the poor effect of operation and local administration.At present, the methods of treating bacterial biofilm in clinic are local mechanical debridement, negative pressure therapy, local medicine and so on. Although it has certain therapeutic effect, bacterial biofilm is still a thorny problem in clinical treatment of chronic infection.In recent years, scholars at home and abroad have put forward some new treatment methods and ideas, such as photodynamic therapy, low-energy phototherapy, acetic acid and antimicrobial peptides, etc.This article reviews the research progress of bacterial biofilm treatment in infected wounds at home and abroad in order to bring inspiration to the clinical treatment and nursing of biofilm.