右美托咪定及咪达唑仑分别应用于AECOPD伴呼吸衰竭治疗的效果观察

Efficacy of Dexmetomidine and Midazolam in the Treatment of AECOPD with Respiratory Failure

目的观察右美托咪定及咪达唑仑在慢性阻塞性肺疾病急性加重期(AECOPD)伴呼吸衰竭患者机械通气治疗过程中镇静效果。方法选择在我院进行治疗的92例AECOPD伴呼吸衰竭患者作为研究对象,按照随机数字表法分为实验组和对照组,每组46例。实验组给予盐酸右美托咪定注射液治疗,对照组给予咪达唑仑注射液治疗。观察两组患者的镇静效果和镇静情况(停药后清醒时间、机械通气时间、ICU住院时间)。结果实验组患者停药后清醒时间、机械通气时间和ICU住院时间均短于对照组,镇静有效率高于对照组,差异均有统计学意义(P<0.05)。结论右美托咪定在AECOPD伴呼吸衰竭患者机械通气治疗过程中镇静效果好,有利于促进患者病情转归、改善预后。

Objective To observe the sedative effect of dexmetomidine and midazolam on mechanical ventilation in （AECOPD） patients with respiratory failure in acute exacerbation of chronic obstructive pulmonary disease.Methods 92 AECOPD patients with respiratory failure were selected as the study subJects.According to the random digital table method,patients were divided into experimental group and control group with 46 cases in each group.The experimental group was treated with dexmetomidine hydrochloride and the control group with midazolam inJection.The sedation effect and sedation were observed in the two groups （waking time, mechanical ventilation time and ICU hospitalization time after withdrawal）. Results The waking time, the time of mechanical ventilation and the hospitalization time of ICU in the experimental group were shorter than those in the control group, and the sedation effective rate was higher than that in the control group,the difference was statistically significant （P〈0.05）.Conclusion The sedation effect of dexmetomidine in the treatment of AECOPD patients with respiratory failure is good, which is helpful to promote the prognosis of patients with respiratory failure.