血清CA125联合CA19-9检测对评估子宫内膜异位症病情及术后复发的临床价值

The clinical value of serum CA125 combined with CA19-9 for assessing the illness state and postoperative recurrence of patients with endometriosis

目的:探讨血清CA125联合CA19-9检测评估子宫内膜异位症(EMT)病情及术后复发的临床价值。方法:选择2014年1月-2016年2月本院收治的EMT患者100例,根据病情分为Ⅰ、Ⅱ期31例,Ⅲ期41例,Ⅳ期28例;术后随访1年,根据术后复发情况分为康复组(81例)与复发组(19例),检测所有患者血清CA125、CA19-9水平及经期疼痛评分,应用ROC曲线法评估CA125、CA19-9预测EMT复发的敏感性。结果:患者血清CA125、CA19-9水平在病情分期比较Ⅰ、Ⅱ期<Ⅲ期<Ⅳ期(P<0.05);血清CA125与CA19-9水平呈正相关性(r=0.758,P<0.05);复发组血清CA125、CA19-9水平显著高于康复组(P<0.05);ROC曲线评估EMT患者术后复发,血清CA125以37.25U/ml为截断点,敏感度、特异度分别为66.7%和90.7%;血清CA19-9以40.50ug/ml为截断点,敏感度、特异度分别为37.5%和95.32%;CA125联合CA19-9评估敏感度、特异度分别为79.2%和97.68%。结论:血清CA125联合CA19-9检测对评估EMT病情,预测术后复发具有较高敏感性。

Objective To explore the clinical value of serum CA125 combined with CA19 9 for assessing the illness state and postoperative recurrence of patients with endometriosis. Methods： From January 2014 to February 2016, 104 patients with endometriosis in Shiyan taihe hospital of Hubei province were selected and divided into stage I group （31 cases）, stage II group （31 cases）, stage III group （41 cases）, and stage IV group （28 cases） according to the illness state. At the same time, all included women also were divided into rehabilitation group （81 cases） and the recurrent group （19 cases） according to whether postoperative recurrence. Serum CA125 and CA19 9 levels of all patients were detected. Serum CA125 and CA19 9 levels and pain scores of patients in menstrual period were compared among the groups. ROC curve was used to evaluate the sensitivity of serum level of CA125 or CA19 9 for predicting recurrence of patients with endometriosis. Results： The serum levels of CA125 and CA19 9 of patients in stage I and II groups were signifficent lower than those of patients in stage III group （ P 〈0.05）, and the serum levels of CA125 and CA19 9 of patients in stage III group were signifficent lower than those of patients in stage IV group （ P 〈0.05）. There was a positive correlation between serum level CA125 and serum level CA19 9 （ r=0.758, P 〈0.05）. The serum levels of CA125 and CA19 9 of patients in recurrent group were significant higher than those of patients in rehabilitation group （ P 〈0.05）. ROC curve analysis had showed that the cut point of serum level of CA125 for predicting the endometriosis recurrent was 37.25 U/ml, and its sensitivity and specificity was 66.7% and 90.7%, respectively. And the cut point of serum level of serum CA19 9 for predicting the endometriosis recurrent was 40.5μg/ml, and its sensitivity and specificity were 37.5% and 95.3%, respectively. The sensitivity and specificity of serum level of CA125 combined with CA19 9 for predicting the endometriosis recurrence were 79.2% and 97.68%, respectively. Conclusion： Serum levels of CA125 combined with CA19 9 is highly sensitive to assess the illness state and to predict postoperative recurrence of patients with endometriosis.