妊娠高血压病孕妇孕产期NT-pro BNP变化及相关性分析

Change of NT-pro BNP during pregnancy and postpartum of women with pregnancy-Induced hypertension and its correlation analysis

目的:观察妊娠高血压病孕妇在孕产期血清氨基末端B型利钠肽前体(NT-pro BNP)的动态变化及与心功能的相关性。方法:运用电化学免疫发光技术检测48例妊娠高血压病孕妇与43例体检健康孕妇在妊娠期和产后6周的血清NT-pro BNP水平,彩色超声心动图评价孕妇左室舒张功能。结果:NT-pro BNP浓度与妊娠高血压病的严重程度密切相关,随着妊娠进程,妊娠高血压组的NT-pro BNP浓度逐渐增高,在妊娠晚期达到高峰,产后6周逐渐降低。二尖瓣血流频谱AVTI与NT-proBNP呈正相关,E峰速度时间积分(EVTI)与NT-proBNP呈负相关。结论:NT-pro BNP的动态检测可作为反映患者妊娠高血压的严重程度及心功能检测的敏感指标,可为临床监测和干预提供依据。

Objective To observe the dynamic changes of NT pro BNP, and to explore its correlation with cardiac function of pregnant women with pregnancy Induced hypertension. Methods： Serum NT pro BNP concentration levels of 48 pregnant women with pregnancy induced hypertension and 43 healthy pregnant women were measured during pregnancy and 6 weeks postpartum by electrochemiluminescence immunoassay. The left ventricular diastolic functions of all pregnant women were evaluated by color echocardiography. Results： The concentration of NT pro BNP was closely related to the severity of pregnancy Induced hypertension. With the gestational weeks of pregnant women increased, the NT pro BNP concentration of pregnant women with pregnancy Induced hypertension gradually increased, and peak of the NT pro BNP concentration had occurred in late pregnancy stage, and then the NT pro BNP concentration had decreased gradually 6 weeks postpartum. The mitral flow spectrum AVTI was positively correlated with NT proBNP concentration, and EVTI was negatively correlated with NT proBNP concentration. Conclusion： The dynamic detection of NT pro BNP concentration can be used as a sensitive index to reflect the severity of pregnancy Induced hypertension and the cardiac function of pregnant women, so It can provide evidence for clinical monitoring and intervention.