食管病变内镜下治疗术后狭窄的危险因素分析

Risk factors of esophageal stricture after endoscopic therapy for early esophageal cancer and precancerous lesions

目的分析食管病变内镜下治疗术后食管狭窄发生的可能危险因素。方法回顾性分析2009年10月至2016年12月我科167例经内镜下治疗的早期食管癌或癌前病变患者资料,分析术后狭窄可能的影响因素。结果 21例患者出现术后食管狭窄,狭窄发生率为12. 6%;与146例未发生术后食管狭窄患者进行对比,两组患者在性别、年龄、病变位置方面差异均无统计学意义(P> 0. 05)。狭窄组食管病变长度明显高于未狭窄组[(41. 2±28. 7) mm vs (33. 9±22. 1) mm];食管病变环周范围越大,内镜治疗术后食管狭窄发生率越高。结论早期食管癌及癌前病变的长度及环周范围是发生内镜治疗术后食管狭窄的危险因素。

Objective To analyze the risk factors of esophageal stricture after endoscopic therapy for early esophageal cancer and precancerous lesions. Methods One hundred and sixty-seven cases of early esophageal cancer and precancerous lesions treated by endoscopic therapy from Oct. 2009 to Dec. 2016 were analyzed,the risk factors of postoperative stricture were analyzed. Results Twenty-one（ 12. 6%） patients were suffered esophageal stricture after endoscopy therapy. Gender,age and lesion location showed no difference between esophageal stricture and control group which consisted of 146 patients（ P〉0. 05）. The lesion length of esophageal stricture group was longer than that of control group [（ 41. 2 ± 28. 7） mm vs（ 33. 9 ± 22. 1） mm]. The rate of stricture was related to lesion＇s circumferential extension. Conclusion Length and circumferential extension of the lesions are the risk fators of stricture after endoscopic therapy for early esophageal cancer and precancerous lesions.