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P450 1A1蛋白生物信息学分析

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摘要 CYP1A1基因编码细胞色素P450 1A1蛋白。该蛋白是重要的活化多环芳烃类致癌物的主要酶类。本文对P4501A1蛋白的基本特性进行了初步预测和分析。通过分析其氨基酸的组成表明P450 1A1蛋白组成比例最高的为亮氨酸,占比10.2%。疏水性分析表明P450 1A1蛋白整体呈现为亲水性。利用PSORT对其进行亚细胞定位表明P450 1A1主要分布于细胞质中,这与大多数蛋白的分布一致。其后采用同源建模方法,构建了P450 1A1的三级结构模型,从预测结果来看,P450 1A1蛋白主要以α-螺旋为其主要结构。这些结果是对P450 1A1蛋白的初步分析,为更进一步地了解P450 1A1蛋白提供了帮助。
作者 易灵
出处 《化工管理》 2018年第33期102-104,共3页 Chemical Engineering Management
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