微环境对造血系统的调控作用研究

Modeling and Simulation of hematopoietic system regulated by microenvironment

造血系统是具有重要意义的复杂动态系统,该系统的调节失控会引发一系列的血液疾病。通过引入自我更新、分化和凋亡等机制,本文建立了一个包含造血干细胞、祖细胞和成熟血细胞的三房室造血系统模型,研究了微环境对造血系统的反馈和调控机制。利用该模型仿真了衰老造血系统各成分随时间的变化情况,仿真结果与临床数据相符的。

Hematopoietic system is a complex and dynamic system of great significance.The disorder of regulation of this system can cause a series of blood diseases. By introducing the mechanisms of self-renewal,differentiation and apoptosis,a three-compartment hematopoietic system model including hematopoietic stem cells,progenitor ceils and mature blood cells was established.The model was then used to simulate the changes of components of the aging hematopoietic system with time and the simulation results were consistent with the clinical data.