术前血清白蛋白对Ⅱ～Ⅲ期食管鳞癌预后的预测价值

Predictive value of preoperative serum albumin on the prognosis of stage Ⅱ-Ⅲ esophageal squamous cell carcinoma

目的探讨术前血清白蛋白(albumin,ALB)是否可作为Ⅱ~Ⅲ期食管鳞癌患者预后的预测指标。方法回顾性分析2012年1月~2015年1月我院217例Ⅱ~Ⅲ期食管鳞癌手术患者的临床资料。根据术前血清ALB含量分为两组:ALB≥35.0 g/L组(189例)和ALB<35.0 g/L组(28例),采用Kaplan-Meier法进行生存分析,并进行单因素及多因素分析。结果两组总生存期(overall survival,OS)差异有统计学意义(P=0.043)。单因素分析表明术前ALB、肿瘤分化程度、TNM分期与患者OS差异有统计学意义(P<0.05)。多因素分析表明仅肿瘤分化程度和TNM分期是独立预后因素。结论术前ALB是预测Ⅱ~Ⅲ期食管鳞癌患者预后的重要指标,但不是影响OS的独立因素。

Objective To investigate whether preoperative serum albumin（ALB） can be used as a predictor of prognosisin patients with stage Ⅱ～Ⅲ esophageal squamous cell carcinoma. Methods The clinical data of 217 patients withstage Ⅱ～Ⅲ esophageal squamous cell carcinoma in our hospital from January 2012 to January 2015 were retrospectively analyzed. According to preoperative serum ALB content, the patients were divided into two groups： ALB〈35.0 g/Lgroup（189 cases） and ALB〈35.0 g/L group （28 cases）. Kaplan-Meier method was used for survival analysis, and univariate and multivariate analysis was carried out. Results There was a statistically significant difference in overall survival（OS） between the two groups（P=0.043）. Univariate analysis showed that preoperative ALB, tumor differentiation, TNMstaging were statistically different with patients＇ OS（P〈0.05）. Multivariate analysis showed that only tumor differentiation degree and TNM staging were independent prognostic factors. Conclusion Preoperative ALB is an important predictor of prognosis in patients with stage Ⅱ～Ⅲ esophageal squamous cell carcinoma, but it is not an independent factor that affects OS.