不同呼气末正压下神经调节辅助通气对AECO PD患者呼吸功的影响分析

Analysis on the effects of neuromodulation assisted ventilation under different positive end-expiratory pressure on the respiratory function in the patients with AECOPD

目的探讨不同呼气末正压下神经调节辅助通气对AECOPD患者呼吸功的影响。方法选取2015年6月~2016年6月在我院治疗的80例AECOPD患者,将80例患者分为研究组和对照组,每组40例,对照组患者采用3 cmH2O的呼气末正压,研究组患者采用9.8 cmH2O的呼气末正压。治疗后,观察两组患者血常规、排痰量以及肺功能的差距。结果研究组治疗总有效率为95.0%,明显高于对照组的80.0%,差异有统计学意义(P<0.05);治疗前,两组患者的FEV1%(第1秒用力呼气容积)、FEV1%/FVC(第1秒呼气容积同肺活量之间的比值)、6MWT(6 min步行试验)和FEV1未出现明显差异(P>0.05),在治疗后,研究组的FEV1%、FEV1%/FVC、6MWT和FEV1水平明显高于对照组(P<0.05)。结论神经调节辅助通气对于AECOPD患者有明显的治疗效果,并且呼气末正压越高,对AECOPD患者的治疗效果越好,能够明显改善患者的肺部功能,值得进一步推广和应用。

Objective To explore the effect of neuromodulation assisted ventilation under different positive end-expiratory pressure on the respiratory function in the patients with AECOPD. Methods A total of 80 patients with AECOPDwho were treated in our hospital from June 2015 to June 2016 were selected. 80 patients were divided into study groupand control group, with 40 cases in each group. In the control group, positive end-expiratory pressure of 3 cmH2O wasused. In the study group, positive end-expiratory pressure of 9.8 cmH2O was used. After treatment, the differences inblood routine test, sputum discharge volume, and lung function between the two groups were observed. Results The totaltreatment efficiency of the study group was 95.0%, was significantly higher than that 80.0% of the control group, thedifference was statistically significant （P〈0.05）. Prior to treatment, there were no significant differences in FEV1%（forced expiratory volume in the first second）, FEV1%/FVC （ratio of expiratory volume in the first second versus lungcapacity）, 6MWT（6-min walk test）, and FEV1 in both groups（P〉0.05）. After treatment, the levels of FEV1%, FEV1%/FVC, 6MWT, and FEV1 in the study group were significantly higher those that in the control group（P〈0.05）. Conclusion Neuromodulation-assisted ventilation has a significant therapeutic effect on AECOPD patients, and the higher positive end-expiratory pressure, the better the therapeutic effect for AECOPD patients, which can significantly improvethe patients＇ lung function, and is worthy of further promotion and application.