抗精神病类药物中毒患者应用纳洛酮急救的价值评估

Evaluation on Application Value of Naloxone in Emergency Treatment of Patients with Poisoning by Antipsychotic Drugs

目的研究与分析抗精神病类药物中毒患者应用纳洛酮急救的价值。方法选取在2014年1月—2017年12月时间内来该院进行急救的患有抗精神类药物中毒的69例患者,随后分为常规治疗组与纳洛酮组。其中该院医师对常规治疗组患者采取常规的方法进行抢救治疗,而医师对纳洛酮组患者采取常规抢救治疗的基础上,联合采取纳洛酮药物进行急救,随后观察两组患者的催醒时间以及不良反应发生情况。结果纳洛酮组与常规治疗组患者的催醒时间以及不良反应发生情况等数据差异显著,前者[(4.52±1.28)h,(8.28±1.94)h,(18.13±5.32)h,5.7%]显著优于后者[(7.21±1.22)h,(13.48±4.79)h,(28.25±6.04)h,29.4%],数据对比差异有统计学意义(t/χ~2=3.610 3,3.633 2,4.621 2,4.612 3,P<0.05)。结论抗精神病类药物中毒患者应用纳洛酮急救的价值较高,值得进一步推广。

Objective To investigate the application value of naloxone in emergency treatment of patients with poisoning by antipsychotic drugs. Methods 69 cases of patients with poisoning by antipsychotic drugs for emergency in our hospital from January 2014 to December 2017 were selected and randomly divided into two groups, the routine group used the routine therapy, while the observation group were treated with naloxone on the basis of the control group, and the wake-up time and occurrence of adverse reactions of the two groups were observed then. Results The differences in the wake-up time and occurrence of adverse reactions between the two groups were obvious, and the indicators in the observation group were obviously better than those in the control group[（4.52±1.28）h, （8.28±1.94）h, （18.13±5.32）h, 5.7% vs （7.21±1.22）h, （13.48±4.79）h, （28.25±6.04）h, 29.4%], and the differences were statistically significant （t/χ^2=3.610 3, 3.633 2, 4.621 2, 42.612 3, P〈0.05）. Conclusion The application value of naloxone in emergency treatment of patients with Poisoning by antipsychotic drugs is higher, which is worth further promotion.