预激方案治疗急性髓系白血病以及难治复发性急性髓系白血病的临床研究

Clinical Study on Priming Induction Regimen in Treatment of Acute Myeloid Leukemia and Refractory and Recurrent Acute Myeloid Leukemia

目的研究并分析预激方案治疗急性髓系白血病以及难治复发性急性髓系白血病的疗效。方法在2013年2月—2018年6月间收治的急性髓系白血病以及难治复发性急性髓系白血病患者中选择64例进行治疗,依据信封法分组,对照组采用MA方案,观察组则采用改良预激方案(HAAG)进行治疗,各32例。对比两组的治疗效果。结果比较CR率,观察组为62.5%,显著高于对照组,差异有统计学意义(χ~2=5.067,P<0.05)。对比治疗总有效率,观察组为78.1%,与对照组比较更高,差异有统计学意义(χ~2=4.433,P<0.05)。对比感染率,观察组为25.0%,明显低于对照组90.6%,差异有统计学意义(χ~2=26.195,P<0.05)。对比血液学毒性,结果提示观察组中性粒细胞(17.3±2.4)与血小板(19.4±2.7)L所得结果更佳,差异有统计学意义(t=18.313,11.284,P<0.05)。结论改良预激方案(HAAG)治疗急性髓系白血病以及难治复发性急性髓系白血病的效果更佳,值得推广。

Objective To investigate the curative effect of priming induction regimen in treatment of acute myeloid leukemia and refractmT and recurrent acute myeloid leukemia. Methods 64 cases of patients with acute myeloid leukemia and refractorT and recurrent acute myeloid leukemia admitted and treated in our hospital from February 2013 to June 2018 were selected and divided into two groups with 32 cases in each, the control group used the MA plan, while the observation group used the modified HAAG treatment, and the treatment effect was compared between the two groups. Results The CR rate in the observation group was obviously higher than that in the control group, which was 62.5% in the observation group, the different was statistically significant（χ^2=5.067, P〈 0.05）, and the total treatment effective rate in the observation group was higher than that in the control group, the different was statistically significant （χ^2=4.433, P〈 0.05）, and the effective rate was 78.1% in the observation group, and the infection rate in the observation group was obviously lower than that in the control group 25.0% vs 90.6%（χ^2=26.195, P〈 0.05） and the neutrophile granulocyte （17.3±2.4）L and platelet （19.4±2.7）L results in the observation group were better,the different was statistically significant （t=18.313, 11.284, P〈0.05）. Conclusion The effect of modified HAAG in treatment of acute myeloid leukemia and refractory and recurrent acute myeloid leukemia is better, which is worth promotion.