化疗对年轻卵巢恶性肿瘤患者卵巢功能的影响分析

Analysis of Effect of Chemotherapy on the Ovarian Function of Young Patients with Ovarian Malignant Tumors

目的探讨对进行卵巢恶性肿瘤手术患者保留生育功能患者在受化疗后对卵巢功能产生的影响进行分析。方法选择该院2014年1月—2018年1月接受卵巢恶性肿瘤手术但是保留生育功能的30例患者,在化疗期间其自身的月经情况和性激素水平还有生育情况等产生的影响进行分析。并且将同期采取卵巢上皮交界性肿瘤行保留生育功能手术后并未接受化疗的28例患者进行对比,分别为化疗组与对照组。结果在对照组中的28例患者里,术后2例(7.14%)产生了月经减少的情况,但是并未产生停经。其和化疗组之间(9例月经减少,12例停经)进行对比,存在的差异有统计学意义(χ~2=5.631 1,9.662 3,P=0.023 5,0.015 2)。化疗组的30例患者里,其中有12例在日后想要进行生育,其中有4例则已经成功的完成妊娠并分娩;对照组中14例具备生育需要的患者,8例成功的完成妊娠分娩,子代都非常健康并未出现畸形的状况)。在化疗组里,有2例患者已经死亡,其余28例则保持无瘤生存;对照组完全保持无瘤生存存在的差异有统计学意义(χ~2=3.621 3,P=0.035 4)。结论对于年轻妇女卵巢恶性肿瘤采取保留生育功能的手术之后进行化疗,会对卵巢功能造成一定的损害,可是其对于子代并不会造成显著的致畸作用。

Objective To study the effect of chemotherapy on the ovarian function of young patients with ovarian malig- nant tumors and reserving the fertility function. Methods 30 cases of patients with ovarian malignant tumors and re- serving the fertility function admitted and treated in our hospital from January 2014 to January 2018 were selected, and the effect on the menstrual condition and sex hormone level during the chemotherapy period was analyzed., and 28 eases of epithelial ovarian borderline tumor patients with fertility preservation surgery but without chemotherapy were selected as the control group, while those 30 cases were used as the chemotherapy group. Results Of 28 cases in the control group, 2 cases （7.14%） had the spanomenorrhea without menolipsis, and in the chemotherapy group, 9 cases had spanomenorrhea, while 12 cases had menolipsis, and the differences between groups were statistically significant（χ^2=5.631 1, 9.662 3, P=0.023 5, 0.015 2）. Of 30 cases in the chemotherapy, 12 cases wanted to give birth in the future, 4 cases had finished the pregnancy and given birth successfully, in the control group, 14 cases had the need to give birth, 8 cases had finished the pregnancy and delivery successfully, and their daughters and sons were very health without malformation, in the chemotherapy group, 2 cases died, and the other 28 cases survived without tumors, and the difference between the two groups was statistically significant （χ^2=3.621 3, P=0.035 4）. Conclusion The chemotherapy after the surgert of young women with ovarian malignant tumors and reserving the delivery function can have a certain injury to the ovarian function, but it can not impose an obvious teratogenesis effect on their daughters and sons.