缺血后适应在急性心肌梗死介入治疗中对梗死面积及心功能的影响研究

Effect of ischemic post-conditioning on infarct area and cardiac function in the interventional treatment of acute myocardial infarction

目的分析缺血后适应在急性心肌梗死介入治疗中对梗死面积及心功能的影响。方法以本院收治的急性心肌梗死患者中抽取70例行介入治疗的患者纳为研究对象,随机分为对照组(35例,非缺血后适应)和观察组(35例,缺血后适应)。对照组待各血管再通后不加干预,观察组待血管再通后行短暂再闭塞。对血肌酸磷酸激酶(CK)、肌酸磷酸激酶同工酶(CK-MB)、校正TMI帧数、ST回落率进行测定,并进行比较。结果观察组CK峰值、CK-MB峰值、CTFC、CK-MB曲线下面积、NT-proBNP明显优于对照组,对比差异存在统计学意义(P<0.05)。结论在急性心肌梗死介入治疗中,缺血后适应可有效缩小梗死面积,改善患者心功能。

Objective To analyze after ischemia to adapt to the interventional treatment in acute myocardial infarction in the infarction area and the influence of cardiac function. Methods In our hospital patients with acute myocardial infarction （mi） extract, 70 patients who underwent interventional treatment as the research object, were randomly divided into control group （35 cases, not adapt to） after ischemia and observation group （35 cases, adaptation after ischemia） controls for each recanalization after without intervention, recanalization group stay short again after occlusion of blood creatine phosphokinase （CK）, creatine phosphokinase isoenzyme （CK-MB） correction TMI dropped frames ST rate were measured, and the comparison. Results The area of nt-pro BNP under CTFC ck-mb curve of CK peak value was significantly better than that of the control group, and the difference was statistically significant （P〈 0.05）. Conclusion In the interventional treatment of acute myocardial infarction, ischemic post-conditioning can effectively reduce the infarct area and improve the cardiac function of patients.