摘要
肝脏疾病是指由各种原因导致的急慢性肝脏病变。肝脏疾病患者由于受到病毒性肝炎、细菌衍生物、内毒素等多种因素的刺激,导致血管内皮细胞活化和损伤。血管性血友病因子(VWF)作为血管内皮细胞功能的特异性标志物,其在肝脏疾病的发生、发展过程中也发挥着重要的作用。现就VWF与肝脏疾病关系的研究进展进行综述。
Hepatic diseases refer to acute and chronic liver disease linked to all kinds of hepatic pathological changes. Viral hepatitis, bacterial infections, endotoxins and other factors initiate the activation and injury of vascular endothelial cells in patients with liver diseases. Von Willebrand factor (vWF) represents a specific marker of endothelial dysfunction and plays a vital role in the occurrence and development of hepatic diseases. This paper reviews the research progress of the relationship between vWF and hepatic diseases.
作者
王琪
赵益明
Wang QL;Zhao Yiming(The First Affiliated Hospital of Soochow University,Jiangsu Institute of Hematology,Key Laboratory of Thrombosis and Hemostasis of Ministry of Health,Suzhou 215006,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2018年第11期877-880,共4页
Chinese Journal of Hepatology
基金
国家自然科学基金项目(81270593,81873431)
关键词
血管陛血友病因子
肝脏疾病
血管内皮
Von Willebrand factor(VWF)
Hepatic diseases
Vascular endothelium