血管性血友病因子与肝脏疾病关系的研究进展

Research progress of the relationship between von WiUebrand factor and hepatic diseases

肝脏疾病是指由各种原因导致的急慢性肝脏病变。肝脏疾病患者由于受到病毒性肝炎、细菌衍生物、内毒素等多种因素的刺激，导致血管内皮细胞活化和损伤。血管性血友病因子（VWF）作为血管内皮细胞功能的特异性标志物，其在肝脏疾病的发生、发展过程中也发挥着重要的作用。现就VWF与肝脏疾病关系的研究进展进行综述。

Hepatic diseases refer to acute and chronic liver disease linked to all kinds of hepatic pathological changes. Viral hepatitis, bacterial infections, endotoxins and other factors initiate the activation and injury of vascular endothelial cells in patients with liver diseases. Von Willebrand factor （vWF） represents a specific marker of endothelial dysfunction and plays a vital role in the occurrence and development of hepatic diseases. This paper reviews the research progress of the relationship between vWF and hepatic diseases.