基于超分子“印迹模板”分析的中药毒与效整合模式探讨

Developing an integrated model of toxicity and efficacy of Chinese medicine based on supramolecular “imprinting template” analysis

中药是中医治病的物质基础,既遵循中医基础理论指导,也遵循药物作用普遍规律,毒与效并存。其毒与效的整合规律彰显于方剂学中,以"七情"和"阴阳"和合的配伍经验定性表征。当按中医药理论遣方口服用药仍产生毒性,或传统中药给药方式被打破,其靠经验来维系的中药毒与效的整合规律就显得束手无策,特别是近年来随着中药现代化和中药新药创制不断推进,中药安全性事件频发,建立一套适用多成分中药的毒与效的整合方法非常迫切。随着生物超分子化学不断与中医药基础理论结合,一种基于中药超分子"印迹模板"毒与效的整合模式初见端倪。中药与人体都是生物超分子体,应遵循超分子"印迹模板"自主作用规律,其所产生毒与效的整合效果是建立在单味中药成分基础上按中医药基础理论据证依法遣药组方治病的整合结果,亦是各单味中药有效成分群按"印迹模板"综合作用的结果,通过对各成分群超分子"印迹模板"特征、作用规律及其网络药(毒)理谱学的定性定量研究,建立以整合成分"治疗窗"表征的毒与效整合分析方法,并找出高溢、进入和低溢"治疗窗"成分的分布规律。

Chinese material medica（CMM） is the foundation for treating disease using traditional Chinese medicine（TCM）,which is not only guided by the basic theory of TCM but also follows the general rules of drug action.There are both toxicity and efficacy in TCM.For TCM the integrated regularities of its toxicity and efficacy were demonstrated in their prescription,which were qualitatively characterized by compatible experiences such as ＂seven emotions＂,＂Yin＂ and ＂Yang＂ compatibility,etc.When the toxicity is still produced by oral administration according to the prescription of TCM theory or administration is not abided by original requirement,the integral regularities of toxicity and efficacy that depends on experience appears to be at a loss what to do.Especially in recent years,with the modernization of TCM and the continuous advantages in new medicinal innovation,the CMM safety incidents occurred frequently.It is very urgent for us how to establish a set of integrated methods that are adequately situated to multiple components for TCM.With the combination of the biological supramolecular chemistry and the basic theory of TCM,an integrated model of toxicity and efficacy based on TCM supramolecular ＂imprinting template＂ has begun to take shape.The CMM and the human body are both biological supramolecular bodies that follow the autonomic action rules of their ＂imprinting template＂.The integrated trends of toxicity and efficacy are able to build on systematical results of single components in CMM based on the theory of TCM to treat diseases by prescription on syndromes.It is also the systematic actions resulting from single effective components in CMM by the supramolecular ＂imprinting template＂ self-acted regularities.Through the qualitative and quantitative analysis of supramolecular ＂imprinting templates＂ characteristics and actions and their network chromatotoxicometrology（chromatopharmacometrology）,a toxic and effective integrated analysis methods will be established on an integrated ＂therapeutic window＂ for components in the CMM.This effort will finally permit the description of the components of the pharmacokinetic overlaid law of ＂therapeutic window＂,plotted to lower-overflow,entering and higher-overflow profiles.