丰富环境运动干预调节学习记忆和Aβ沉积改善AD病理的作用研究

Research of Exercise in Environmental Enrichment on Regulating Learning and Memory and Aβ Deposition to Alleviate Pathology of Alzheimer's Disease

丰富环境运动干预是区别于普通运动干预的一种动物实验干预方式。研究发现对实验小鼠施加长期的丰富环境运动干预对改善脑认知功能和缓解脑退行性疾病效果显著。大量实验研究将丰富环境中加入小鼠跑转轮或爬梯等运动装置,用于对阿尔茨海默病(Alzheimer’s disease,AD)实验小鼠进行干预,发现丰富环境中的运动对促进AD小鼠认知功能的改善,以及调节脑神经元β-淀粉样蛋白(β-amyloid,Aβ)的沉积,缓解其神经细胞毒性方面具有积极的作用。因此,丰富环境干预可通过调节AD病理的关键致病因子Aβ的水平而起到缓解AD发病的效果。本文将从丰富环境运动干预对学习记忆能力和Aβ沉积的调节机制进行阐述,以期阐明丰富环境结合运动干预对缓解AD病理机制的作用。

Exercise intervene in environmental enrichment is a special animal experiment means, which is different from ordinary exercise intervention model. Studies found that environmental environment to been a positive effect on alleviating degenerative disease of brain when provided it for a long time. A large number of experimental studies chose environmental environment, in which a running wheel or a ladder is included, as an intervene ways to alleviate Alzheimer’s disease （AD） in animal models of AD, and found that environmental environment had positive effects in promoting cognitive function in animal models of AD and regulating neuronal toxicity of β-amyloid （Aβ）. Environmental environment may have effects on alleviating AD by regulating Aβ, which is known as the key factor of AD pathology. In order to found the molecular biology mechanism of Exercise intervene in environmental enrichment alleviate AD, in the present study, we will discuss how environmental environment to regulate learning and memory and Aβ level, and hope to illuminate pathomechanism of environmental environment bond with exercise for alleviating AD.