几丁质酶-3样蛋白-1与冠心病患者冠脉病变狭窄程度的相关性分析

Correlation between serum chitinase 3 like 1(YKL-40) level and severity of coronary artery stenosis in patients with coronary heart disease

目的通过检测几丁质酶-3样蛋白-1(YKL-40)的水平,探讨该新型生物标记物与冠心病患者冠脉狭窄程度的关联。方法纳入2015年1月1日-2017年10月1日于解放军总医院心血管内科行冠状动脉造影诊断为冠心病的患者200例,测定所有患者YKL-40的水平,并对所有患者进行Syntax评分及定量冠状动脉造影分析以判断冠脉狭窄严重程度。结果 Syntax评分低分组、中分组、高分组患者YKL-40水平分别为(136.18±14.00) mmol/L、(158.36±12.39) mmol/L、(181.18±12.94) mmol/L;此外,随冠脉狭窄程度增加,YKL-40水平呈升高趋势,YKL-40水平与冠脉狭窄程度呈正相关(r=0.808,P <0.05)。结论冠心病患者YKL-40水平与冠脉病变狭窄程度正相关,YKL-40可作为评估冠脉狭窄程度的生物标记物。

Objective To investigate the correlation between serum chitinase 3 like 1（YKL-40） and the severity of atherosclerotic plaque in patients with coronary heart disease（CHD）. Methods Two hundred consecutive patients with CHD who underwent coronary angiography in the cardiology department of Chinese PLA General Hospital were recruited from January 1, 2015 to October 1, 2017. Serum YKL-40 was assessed in all patients. Meanwhile, Syntax score and quantitative coronary angiography were used to measure the severity of coronary stenosis. Results The YKL-40 level of low, moderate, high Syntax score group was（136.18±14.00） mmol/L,（158.36±12.39） mmol/L,（181.18±12.94） mmol/L, respectively. The level of YKL-40 increased with the severity of atherosclerotic plaque. Pearson correlation test showed that the level of YKL-40 was positively correlated with the degree of coronary stenosis（r=0.808, P〈0.05）. Conclusion This study shows that the level of YKL-40 in patients with coronary heart disease is correlated with the degree of stenosis of atherosclerotic plaque. YKL-40 can be used as a biomarker to evaluate the degree of coronary stenosis.