摘要
目的验证一种新型伤口闭合装置对猪致死性创伤出血模型的止血效果。方法选用10只体质量为30 kg的实验用雄性巴马小型猪,随机分为A、B两组,A组为新型伤口闭合装置止血组,B组为标准纱布加压包扎止血组,每组5只。制作腹股沟股动静脉离断致死性创伤出血模型。分别用两种止血方法对创伤出血模型进行止血实验,主要观测指标包括出血量、生存率、生存时间,次要观测指标包括心率、血压、动脉血氧饱和度。结果实验结束时A组全部存活,平均生存时间> 180 min,B组平均生存时间为129 min。出血量A组(488.78±40.57) g,B组(809.84±127.82) g,差异有统计学意义(P=0.047)。两组动物的心率、血压、血氧饱和度等生理参数无统计学差异。结论与标准纱布加压包扎比较,新型伤口闭合装置在控制严重出血和减少出血量方面更具优势。
Objective To verify the hemostatic effect of a new wound closure device on a porcine fatal traumatic hemorrhage model. Methods Ten male Bama miniature pigs with weight of 30 kg were randomly divided into group A and group B, with 5 pigs in each group. Group A was new wound closure device hemostasis group, while group B was standard gauze pressure bandaging hemostasis group. A swine model of fatal traumatic hemorrhage was established by inguinal femoral arteriovenous disconnection. Two kinds of hemostasis methods were used to stanch the bleeding of the swine traumatic hemorrhage model. The experimental observation time was 3 hours. The main indicators included bleeding volume, survival rate, survival time, and the secondary indicator included heart rate, blood pressure, arterial oxygen saturation. The experimental data obtained from the two methods were statistically analyzed. Results At the end of the experiment, all pigs in group A survived, and the survival time was 180 minutes, while the average survival time of group B was 129 minutes. The amount of bleeding was (488.78±40.57) g in group A and (809.84±127.82) g in group B with significant difference (P=0.047). There was no significant difference in physiological parameters such as heart rate, blood pressure and oxygen saturation between the two groups. Conclusion Compared with the standard gauze dressing, the new wound closure device has advantages in controlling severe bleeding and reducing the amount of bleeding. The new wound closure device can effectively stop bleeding caused by femoral arteriovenous trauma in porcine, and the hemostatic effect is better than that of the standard gauze dressing.
作者
胡传忠
梁向党
王森
孙赓
郭占社
HU Chuanzhong;LIANG Xiangdang;WANG Sen;SUN Geng;GUO Zhanshe(Department of Osteology,Chinese PLA General Hospital,Beijing 100853,China;Daxing District People's Hospital,Beijing 102600,China;Department of Osteology,Chinese PLA 252 Hospital,Baoding 071000,Hebei Province,China;School of Instrumentation Science and Opto-electronics Engineering,Beihang University,Beijing 100191,China)
出处
《解放军医学院学报》
CAS
2018年第10期889-892,924,共5页
Academic Journal of Chinese PLA Medical School
基金
部委级资助项目
后勤保障部军队重点项目(13CX2032)
解放军总医院转化项目(2017TM-016)~~
关键词
创伤
出血
伤口闭合装置
敷料
trauma
hemorrhage
wound closure device
dressing