冠心病支架内再狭窄的危险因素分析

Risk factors of in-stent restenosis for coronary heart disease

目的分析冠心病支架内再狭窄(ISR)的危险因素。方法 102例冠心病患者行经皮冠状动脉内介入治疗,根据术后冠脉造影结果分为ISR组(38例)和非ISR组(64例),分析ISR的危险因素。结果 ISR组中吸烟、糖尿病、心肌梗死、尿酸、总胆固醇、脂蛋白a及术前狭窄程度均高于非ISR组(P<0.01或0.05),总胆红素水平低于非ISR组(P<0.05)。Logistic回归分析显示吸烟、糖尿病、心肌梗死、总胆红素、尿酸及术前狭窄程度为ISR的独立危险因素(P<0.05)。结论冠心病患者发生ISR与吸烟、糖尿病、心肌梗死、总胆红素、尿酸及术前狭窄程度有关。

Objective To analyze the risk factors of in-stent restenosis（ISR） in patients with coronary heart disease（CHD）. Based on postoperative coronary angiography results, 102 CHD patients undergoing percutaneous coronary Methodsintervention were divided into ISR group（n=38） and non-ISR group（n=64） and the risk factors were then analyzed. Results Compared with non-ISR group, smoking, diabetes mellitus, myocardial infarction, uric acid, total cholesterol, lipoprotein a and preoperative stenosis were significantly higher（P〈0.01 or 0.05）, while total bilirubin level was lower（P〈0.05） in ISR group. Logistic regression analysis showed that diabetes mellitus, myocardial infarction, total bilirubin, uric acid and preoperative stenosis were independent risk factors for ISR（P〈0.05）. Conclusion ISR is related to smoking, diabetes mellitus, myocardial infarction, total bilirubin, uric acid, and preoperative stenosis in CHD patients.