阿托伐他汀对高胆固醇血症患者有效性的影响

Effect of atorvastatin on the effectiveness of patients with hypercholesterolemia

目的探讨阿托伐他汀对高胆固醇血症患者临床指标的影响。方法根据随机数字表法将2016年6月~2017年6月90例高胆固醇血症患者分成不同组。对照组给予饮食指导治疗,观察组则给予饮食指导联合阿托伐他汀治疗。观察6个月,比较两组高胆固醇血症治疗效果、血脂控制达标的时间、治疗前后患者脉搏波传导速度、踝肱指数的变化程度、治疗不良反应率。结果观察组高胆固醇血症治疗总有效率高于对照组(P<0.05);观察组血脂控制达标的时间优于对照组(P<0.05);治疗前两组脉搏波传导速度、踝肱指数相近(P>0.05);治疗后观察组脉搏波传导速度、踝肱指数优于对照组(P<0.05)。不良反应方面,观察组5例存在短暂肝功能变化即转氨酶短暂升高。部分病例高于3倍正常值上限的退出试验。有部分患者不能耐受阿托伐他汀的治疗。结论饮食指导联合阿托伐他汀治疗高胆固醇血症的应用效果确切,可有效改善脉搏波传导速度,提高踝肱指数,且无严重不良反应,仅少部分患者因肝脏转氨酶升高而不能耐受阿托伐他汀治疗,值得推广应用。

Objective To investigate the effect of atorvastatin on clinical indicators of patients with hypercholesterolemia. Methods 90 patients with hypercholesterolemia from June 2016 to June 2017 were divided into differentgroups according to the random number table method. The control group was given dietary guidance treatment. The observation group was given dietary guidance combined with atorvastatin. They were observed for 6 months. The therapeutic effects of hypercholesterolemia; the time of blood lipid control reaching to standard; the degree of change of pulsewave velocity and ankle-brachial index before and after treatment; the incidence rate of adverse treatment responseswere compared between the two groups. Results The total effective rate of hypercholesterolemia in the observationgroup was higher than that in the control group（P〈0.05）. The time of blood lipid control reaching the standard in theobservation group was better than that in the control group（P〈0.05）; before treatment, the pulse wave velocity and theankle-brachial index in two groups were similar（P〉0.05）; after treatment, the pulse wave velocity and ankle-brachial index in the observation group were better than those in the control group（P〈0.05）. In terms of adverse reactions, therewere transient liver function changes and a transient increase in transaminases in 5 cases in the observation group. Insome cases, some cases were withdrawn from the experiment due to the value being 3 times higher than the upper limitof the normal value. Some patients were not able to tolerate the treatment of atorvastatin. Conclusion Dietary guidance combined with atorvastatin in the treatment of hypercholesterolemia is effective, which can effectively improve the pulsewave velocity, and increase the ankle-brachial index, with no serious adverse reactions. A small number of patients areunable to tolerate atorvastatin due to elevated liver transaminases, but in general, it is worthy of promotion and application.