浓缩生长因子在雄激素源性脱发治疗中的研究进展

Research advance of concentrated growth factors in treatment of androgenetic hair loss

雄激素源性脱发(androgenetic alopecia,AGA)是影响男性和女性最常见的脱发形式,虽然目前已有数种可用的治疗选择,但人们还是在不断寻找一些更有效的治疗手段。浓缩生长因子(concentration growth factor,CGF)作为一种新型血小板制品已经成功应用在诸如骨科、口腔科、颌面外科、整形外科、皮肤科等众多领域,CGF可增强血管生成、细胞外基质重塑以及促进细胞的增殖和分化。CGF含有多种高浓度生长因子以及CD34阳性细胞群,其中的主要成分血小板衍生生长因子(platelet derived growth factor,PDGF)、转化生长因子(transforming growth factor,TGF)、血管内皮生长因子(vascular endothelial growth facto,VEGF)、表皮生长因子(epidermal growth factor,EGF)、胰岛素样生长因子(insulin-like growth factor,IGF)和肝细胞生长因子(hepatocyte growthfactor,HGF)能有效刺激毛囊细胞生长、改善头皮微环境及头皮血供。尽管有可能成为治疗脱发的有效手段,但国内外关于CGF应用于脱发治疗的临床案例及疗效鲜有报道,也没有关于CGF对毛囊作用机制的评论文章。本文的目的在于介绍CGF及其在促进毛发生长中的有效作用机制,为患者的抗脱发治疗提供一种新的手段和方式。

Androgenetic alopecia is the most common form of hair loss that affects both men and women. Although there are already available treatment methods, people are still looking for more effective treatments. As a new type of platelet products. Concentration growth factor （CGF） has been successfully used in many flelds such as orthopedics, oral and maxillofacial surgery, orthopedics, dermatology, etc. CGF enhances angiogenesis, extracellular matrix remodeling, and promotes cell proliferation and differentiation. CGF contains various high concentration growth factor and CD34＋ cell group. The main component of CGF includes platelet derived growth factor （PDGF）, transforming growth factor （TGF）, vascular endothelial growth factor （VEGF）, epidermal growth factor （EGF）, insulin-like growth factor （IGF） and hepatocyte growth factor （HGF）. They can effectively stimulate the hair follicle cell growth, improve blood supply and scalp micro environment. Thus it may act as a means for treating hair loss. However, this potential role has been rarely reported. The purpose of this paper is to introduce the effective mechanism of CGF and its role in promoting hair growth, provide a new method for the treatment of alopecia.