摘要
In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.
In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great ef- forts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarify- ing the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.
基金
partially supported by the MEXT World Premier International Research Center Initiative,CREST JST,MEXT KAKENHI for Scientific Research on Innovative Areas "Microendophenotype"(25116530)and "Memory Dynamism"(26115502)
JSPS KAKENHI Grants(16K18359,15F15408)
Research Foundation for Opto-Science and Technology
Kato Memorial Bioscience Foundation
Japan Foundation for Applied Enzymology
Uehara Memorial Foundation
2016 Inamori Research Grants Program
Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
Life Science Foundation of Japan
Kowa Life Science Foundation Research Grant
GSK Japan Research Grant
KANAE Foundation for the Promotion of Medical Science
Shimadzu Foundation for the Promotion of Science and Technology
Takeda Science Foundation to MS
The Tokyo Biochemical Research Foundation to SS
