Adenosine triphosphate maintenance by branched chain amino acids as a novel neuroprotective strategy for retinal neurodegenerative diseases

Retinal neuronal cell death is caused in many incurable eye diseases such as retinitis pigmentosa(RP)and glaucoma,which are leading causes of adult blindness.In RP,progressive loss of photoreceptor cells leads to visual disturbance.No established treatments are available to date for this condition,although potential treatments,including regenerative medicine,gene therapy,and neurotropic factor therapy are being investigated.In glaucoma。

Retinal neuronal cell death is caused in many incurable eye diseases such as retinitis pigmentosa （RP） and glau- coma, which are leading causes of adult blindness. In RP, progressive loss of photoreceptor cells leads to visual dis- turbance. No established treatments are available to date for this condition, although potential treatments, includ- ing regenerative medicine, gene therapy, and neurotropic factor therapy are being investigated. In glaucoma, retinal ganglion cell death leads to visual disturbance.