紫苏油微胶囊口含片的制备

Preparation of Buccal Tablet of Perilla Oil Microcapsule

以紫苏油微胶囊为主料,采用粉末直接压片法制备口含片。以片剂硬度和感官综合评分为指标,研究配方对片剂成型工艺的影响。结果表明,紫苏油微胶囊口含片的最佳配方为:主辅料比例4︰5,辅料中乳糖与微晶纤维素比例1︰1,蔗糖粉和柠檬酸的添加量分别占主辅料总质量的20%和1.25%。在此条件下口含片色泽均匀,酸甜适口。平均硬度为33.2 N,综合评分32.75分。

With the Perilla oil microcapsules as the main material, the buccal tablet was prepared by the method of powder direct compression. The effect of the formulation on the tablet molding process was studied by the comprehensive score of hardness and sensory as an index. The results showed that the optimum formulation of buccal tablet of Perilla oil microcapsule was as follows： the ratio of main material to excipient 4︰5, the ratio of lactose and microcrystalline cellulose 1︰1, and the addition of sucrose powder and citric acid accounted for 20% and 1.25% of the sum of main material and auxiliary materials. Under this condition, the color and luster of the buccal tablet were uniform, and the acidity and sweetness were moderate. The average hardness was 33.2 N, and the composite score was 32.75.