C-myc及增殖细胞核抗原在小儿肝母细胞瘤中表达及其临床意义

The clinical significance of expression of C-myc and PCNA in the Hepatoblastoma in children

目的 探讨C-myc和增殖细胞核抗原(Proliferating cell nuclear antigen,PCNA)的表达在小儿肝母细胞瘤(Hepatoblastonra,HB)中的临床意义。方法 用免疫组化法检测22例小儿HB组织中C-myc和PCNA的表达。结果 HB组织和正常肝组织中C-myc阳性表达率分别为81.8％(18/22)和33.3％(3/9);PCNA在HB组织和正常肝组织中阳性表达率分别为68.2％(15/22)和阴性(0/9)。HB组织中C-myc和PCNA阳性表达率显著高于正常肝组织(P<0.05)。C-myc和PCNA阳性表达率与HB病理类型无明显相关性(P>0.05),但与肿瘤临床分期呈正相关,临床分期越晚期,C-myc和PCNA阳性率越高。结论C-myc和PCNA在HB中的表达与HB的发生、发展和预后密切相关,对C-myc和PCNA阳性表达率高的晚期HB患儿,术后应给予更积极的治疗。

Objective To investigate the clinical significance of expression of C-myc and PCNA in HB in children. Methods The expression of C-myc and PCNA were examined by immunohistochemical method in 22 children with HB. Results The fraguency of C-myc and PCNA expression in HB was 81.8% (18/22) and 68.2% (15/22) , respectively, that of control group was 33.3%(3/9) ,and nonerespectively.The freguency of C-myc and PCNA expression in HB was significantly higher than that of C-myc and PCNA expression in control groups, No significant rektionships were found between the expression of C-myc and PCNA with histopathological classification of the tumor.Their positive rate was significantly associated with clinical stage of tumor. Conclusions The experssion of C-myc and PCNA correlate with the development and progrosis of HB. The patients with high expression should be give more aggressive postoperative treatments.