3D打印技术在透皮领域的研究进展

Recent Advances of 3D Printing Technology in Transdermal Drug Delivery System

3D打印(3D printing)是一种基于计算机三维模型数据,通过层层打印、逐层叠加的方法制造产品的新技术,具有产品精度高、原料无浪费的独特优势;而经皮给药系统具有安全、可控、患者顺应性好的特点。本文简要概述了3D打印技术在经皮给药领域的研究进展,包括3D打印人工皮肤用于透皮扩散试验、体外构建皮肤病模型探索皮肤病的发病机制及筛选药物、3D打印个性化载药贴片实现精准给药、3D打印微针用于经皮药物的促渗及其机制的探索等,并对3D打印技术在该领域的研究方向做出了展望。

3D printing is a new technology based on computer three-dimensional model data for manufaction by layer-by-layer printing and stacking. It has the unique advantages of high product accuracy, and no waste of raw materials. Transdermal drug delivery system is safe, controllable and patient compliant. Therefore, the combination of above two technologies has attracted more and more attention. Nowadays, researchers mainly focus on printing artificial skin and a variety of microneedles. Firstly, this paper gives a brief overview of the 3D printing technology for transdermal drug delivery system. Then, it summarizes the application of the technology in this field, including printing artificial skin for transdermal diffusion experiment, constructing skin disease model in vitro to explore the pathogenesis of skin diseases and screen drugs, printing personalized patches to realize accurate drug delivery and preparing microneedles for penetration enhancement and mechanism study. In addition, it makes a summary of the application limitations of 3D printing in transdermal drug delivery system in order to give a guide for the future research so that the technology can be put into practical application and industrialization quickly. Finally, it makes prospects for the future research direction of 3D printing technology in this field.