立方液晶作为天然药物载体的研究进展

Research Advance in Cubosomes as Carriers for Natural Medicines

通过以"立方液晶"、"非层状液晶"、"cubosomes"、"cubic liquid crystalline"等为关键词,组合查询PubMed、中国知网、维普和万方数据库中有关于立方液晶的形成机制、相转变影响因素及作为天然药物载体研究的相关文献并进行综述,以期为立方液晶递送系统的深入研究与发展提供借鉴与思考。

Cubosomes are bicontinuous cubic phase liquid crystals, consisting of two non-intersecting water channels and highly twisted bicontinuous lipid bilayer in three dimensions. As a lipid carrier system, cubosomes are attracting more and more attention due to the unique liquid crystalline structures and physicochemical properties. Recently, outstanding properties of cubosomes such as high stability, biodegradability and bioadhesion make them excellent candidates for drug-delivery applications and provide the ability to incorporate and deliver drug molecules in a controlled manner. Through retrieving the related literatures from PubMed, CNKI, CQVIP and WANFANG databases with ＂cubosomes＂, ＂cubic liquid crystalline＂ and ＂cubic phase nanoparticles＂ as keywords, this paper mainly reviews the formation mechanism of cubosomes, the influencing factors for the phase transition of cubosomes and the application to delivery of natural drugs, so as to provide references for the design and development of cubosomes.